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Oral Rivaroxaban for Symptomatic Venous Thromboembolism
Dec 23, 2010 ... for treating acute deep-vein thrombosis (DVT) and for continued treatment, with- .... ued Treatment Study (EINSTEIN–Extension) was.
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Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
Mar 26, 2012 ... who had acute symptomatic pulmonary embolism with or without deep-vein throm- bosis, we ... The EINSTEIN–PE study was a randomized,.
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Oral rivaroxaban after symptomatic venous -
The EINSTEIN-Extension study compared rivaroxaban ... continued treatment study ... oxaban as a standalone drug for the treatment of acute DVT [19];.
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Treatment options for venous thromboembolism: lessons learnt from
Management of VTE in clinical practice is often complex because patients' characteristics and ... for the initial treatment of VTE, with the vitamin K antagonist continued when ... on VTE treatment, recommend that patients with acute proximal DVT or PE .... In both the EINSTEIN DVT and EINSTEIN PE studies, rivaroxaban was ...
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Dosing and Transition Management | XARELTO® (rivaroxaban)
Important Safety Information continued on next page. ... For the reduction in the risk of recurrence of DVT and of PE following ... No clinical trial data are available to guide converting patients from XARELTO® to warfarin .... Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. ... The EINSTEIN Investigators.
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Developments in the management and treatment of pulmonary
Rivaroxaban, apixaban and dabigatran are approved for the treatment of PE ... patients with confirmed acute symptomatic PE with or without symptomatic .... In the EINSTEIN DVT trial, which included patients with DVT but .... Patients who have had an initial PE remain at risk of recurrence without continued therapy [3, 45].
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Rivaroxaban for the treatment of deep vein thrombosis or pulmonary
Sep 17, 2014 ... EINSTEIN-DVT and EINSTEIN-PE: rivaroxaban's pivotal clinical ... EINSTEIN-PE are open-label, randomized non-inferiority studies that evaluated the efficacy and safety of rivaroxaban in patients with acute, symptomatic, proximal DVT .... ACCP suggests continued treatment with the same anticoagulant ...
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About the EINSTEIN-DVT Study - Bayer Investor Relations
EINSTEIN-DVT is a Phase III major outcomes study comparing the efficacy and safety of novel once-daily oral rivaroxaban with enoxaparin followed by a vitamin K antagonist (VKA) in the initial treatment of acute symptomatic deep vein ... VKA; VKA continued if INR≥2 on two consecutive measurements at least 24 hours ...
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Rivaroxaban (Xarelto) - NPS MedicineWise
PE, and in people with acute symptomatic PE with or without DVT, over 3, 6 or 12 months. Rivaroxaban is ... For initial treatment of acute DVT or PE the dose is rivaroxaban 15 mg twice a day for the first 3 .... In the Einstein-PE Study, most participants had ... Continued Treatment Study).7 Most participants in the. Continued ...
[ Rivaroxaban-for-VTE.pdf - Read/Download File

The New Oral Anticoagulants for the Treatment of Venous
Sep 28, 2014 ... The Einstein-Acute DVT study was an open-label, randomized, ... The primary efficacy outcome was symptomatic, recurrent VTE .... were randomly assigned to continue treatment with rivaroxaban 20 mg daily or placebo.
[ 1-s2.0-S0011393X14000113-main.pdf?_tid=962c8a64-570c-11e4-92d4-00000aacb35e&acdnat=1413667410_97f9ab6821b33b74cd76f5a88bf02b6a - Read/Download File

about xarelto clinical studies - Bayer Investor Relations
RECORD1: Both treatments continued for 35+/-4 days. •. RECORD2: ... with acute symptomatic deep vein thrombosis (EINSTEIN-DVT) and acute symptomatic.
[ About_Xarelto_Clinical_Studies.pdf - Read/Download File

Pharmacokinetic and pharmacodynamic evaluation of rivaroxaban
Oct 28, 2014 ... Data from dose-ranging studies, pharmacokinetic modelling and randomised phase III trials ... VKA therapy is continued for as long as the risk of recurrent venous .... ing or recurrence of DVT, confirmed symptomatic PE or VTE-related .... studies. Two acute treatment trials, EINSTEIN DVT and EINSTEIN PE.
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Oral rivaroxaban for Japanese patients with symptomatic venous
Conclusions: The findings of this study in Japanese patients with acute DVT and/ or PE suggest a similar efficacy and safety profile with rivaroxaban and control treatment, consistent with that of the worldwide ... used in the global EINSTEIN DVT and PE studies. ..... tients continued on rivaroxaban and results normalized.
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Rivaroxaban (Xarelto) in the management of stroke and DVT
Sep 5, 2012 ... first three weeks, then 20mg once daily for continued treatment and prevention of ... (vs warfarin) and in the treatment of acute symptomatic DVT (vs enoxaparin, then war- .... EINSTEIN DVT was a trial in 3449 patients with ...
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During the acute VTE phase, Xarelto® is dosed at 15 mg for 21 days
PRIMARY EFFICACY OUTCOME: SYMPTOMATIC RECURRENT VTE. 3 ... Xarelto® is the first oral, single-drug regimen for the treatment of VTE (DVT and PE) ... 68% of subjects had at least 6 months, and around 3% of subjects had at least 12 months in the EINSTEIN DVT trial. ... Treatment continued for 3, 6, or 12 months.
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View PDF - e-Science Central
Nov 3, 2015 ... acute DVT [23]. The EINSTEIN-PE study enrolled 4832 patients who had acute symptomatic pulmonary embolism and compared rivaroxaban ...
[ role-of-novel-oral-anticoagulants-in-primary-and-secondarythromboprophylaxis-in-cancer-2329-8790-1000222.pdf - Read/Download File

XALIA: rationale and design of a non-interventional study of
Jul 14, 2014 ... vitamin K antagonist, for the treatment of acute symptomatic DVT and the secondary prevention of VTE. As the use .... The EINSTEIN PE study investigated rivaroxaban in ... was no clear decision about continuing or stopping.
[ 1477-9560-12-16? - Read/Download File

Detailed Advice (PDF) - Scottish Medicines Consortium
Feb 13, 2012 ... rivaroxaban 15 and 20mg film-coated tablets (Xarelto®) SMC No. ... The recommended dose for the initial treatment of acute DVT is 15 mg twice daily for the first ... five days in combination with a VKA and continued until the international ... EINSTEIN studies, or in routine care, and in whom there was clinical ...
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A Comparison of the Direct Oral Anticoagulants in Treatment of
Apr 8, 2015 ... oral anticoagulants (DOACs) in acute treatment of DVT. Dabigatran ... continued mid- or long-term, with duration depending on presence of risk factors to .... incidence of recurrent symptomatic VTE (fatal or non-fatal PE and DVT) .... EINSTEIN-DVT trial [22] included two studies of rivaroxaban versus warfarin ...
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Bayer - NICE
Rivaroxaban in the treatment of deep vein thrombosis. Page 1 of 230 .... Table 8: Principal findings from EINSTEIN-DVT dose-ranging study . ...... drug approach for the acute and continued treatment of DVT, and does not require .... Prevention Of Recurrent Symptomatic Venous Thromboembolism In Patients With.
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