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Get PDF (856K) - Wiley Online Library
A carrier effect is obtained typically when a hapten-protein conjugate is injec- ... hapten secondary response is usually less than that which would have been.
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The adoptive secondary response of mice to conjugates of NIP (4-hydroxy-S- ... of the hapten and carrier were required: cells primed with BSA, for example,.
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N. A. Mitchison. London. The carrier effect in the secondary response to hapten- protein conjugates. V. Use of antilymphocyte serum to deplete animals of.
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The carrier effect in the secondary response to hapten- protein conjugates. 111. The anatomical distribution of helper cells and anti- body-form ing-cell-precu ...
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1093. The carrier effect in the secondary response to hapten- protein conjugates. IV. Uptake of antigen in vitro and failure to obtain cooperative induction in vitro.
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HAPTEN-SPECIFIC lgE ANTIBODY RESPONSES IN MICE II - NCBI
concerns whether or not the effect of activated helper ~[ cells on IgE production follows the ... DNP-protein conjugate or carrier protein alone mixed with alum. ... Elicitation of Adoptive Secondary Hapten-Specific IgE Antibody Responses.-.
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the role of antibody in t-cell responses - NCBI
cells in carrier-hapten co-operation(Katz, 1972); these can perhaps be grouped ...... The carrier effect in the secondary response to hapten-protein conjugates. II.
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studies on the effect of the carrier molecule on antihapten antibody
clearly demonstrated with regard to the ability of hapten-protein conjugates to stimu- late a secondary response in rabbits (5) or to elicit delayed hypersensitivity ... effect of the carrier upon the antibody response to the 2,4-dinitrophenyl (DNP).
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TWO DISTINCT TYPES OF HELPER T CELLS INVOLVED IN THE
In the antibody response to a hapten.carrier conjugate, the helper T cell is believed to ... interaction is supported by a phenomenon known as the carrier effect, in which the ... cells is readily demonstrable in the adoptive secondary antibody response (5-8). ... were introduced to these proteins by the method of Eisen et al. (30) ...
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THE SPECIFICITY OF CELLULAR IMMUNE RESPONSES IN
Responses of thymus-derived (T) lymphocytes to hapten-protein conjugates are very ...... The carrier effect in the secondary response to hapten-protein.
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IMMUNODEVIATION BY PASSIVE ANTIBODY, AN EXPRESSION
article has indeed shown the differential effect of passive IgG1 and IgG2 anti- hapten antibodies ... IgG2 anticarrier antibodies on the active IgG1 and IgG2 antihapten response. The present ... The conjugated proteins were purified by acid pre- cipitation or by ..... The carrier effect in the secondary response to hapten- protein ...
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HAPTEN-SPECIFIC STIMULATION OF SECONDARY B CELLS
clearly exemplified in the secondary immune response to hapten-carrier complexes where T cells ... can be stimulated by low concentrations of soluble hapten-carrier conjugates, ... Effect of Anti-Theta Serum Treatment on Response of Transferred Secondary B Cells in Organ .... response with dinitrophenylated proteins.
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INDUCTION OF T-LYMPHOCYTE RESPONSES TO A SMALL
responses to hapten-protein conjugates (2-6), we felt that the model of active suppression ..... The carrier effect in the secondary response to hapten-protein.
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THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY
amplification of the secondary response to a haptenic determinant which results from the presence of ... cells from immunized mice which can be stimulated in the absence of carrier recogni- ..... anti-hapten antibody forms large aggregates with hapten-protein conjugates ..... antigen concentration and the carrier effect. J. Exp.
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carrier function in anti-hapten antibody responses iii. stimulation of
Secondary anti-hapten antibody responses to hapten~:arrier conjugates generally ... In general, the proteins and other reagents used here are identical with .... The effect of secondary antigen challenge with a DNP-heterologous carrier: Al-.
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Immunology Pillars of Immunology - The Journal of Immunology
The Carrier Effect and T Cell/B Cell Cooperation in the. Antibody ... triggering the secondary response recognized the hapten to- .... hapten- protein conjugates.
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Dissociation of the Anti-Hapten and Anti-Carrier Responses of Mice
DNP responses, whereas both primary and secondary anti-LPS responses were ... a dissociation of theanti-hapten and anti-carrier antibody responses and sug- .... presented for DNP conjugated to the bacterial cells .... Effect of varying the primary and sec- ..... during the early response to a single injection of protein.
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Evidence for an Immunoglobulin-Dependent Antigen-Specific - JStor
thymus-derived lymphocytes can affect the quality of antibody ... Evidence from adoptive secondary antibody responses demonstrates that both cells are antigen -specific T ... sponses to hapten-protein carrier conjugates involve antibody.
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IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Haptens. Hapten-Carrier Conjugate. Carrier Effect and Carrier Priming ... There are various factors which govern the immune response induction by a ... also known to affect immunogenicity, the reason that proteins are better immunogens as .... (DNP-BSA) and rechallenged (secondary antigen) with either DNP-BSA, BSA or.
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Studies of the Influence of Different Cross-Linking Reagents on the
of the conjugation and on the immune response, at both B-cell and T-cell levels. ... when attached to a carrier protein (8) or coadministrated ... for synthetic vaccines devoid of any side effects, such as ..... cognate interaction between hapten-specific B-cells and .... (11) Mitchison, N. A. (1971) The carrier effect in the secondary.
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