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Synthesis, Physicochemical and Anticonvulsant Properties of New N
Synthesis, Physicochemical and Anticonvulsant Properties of. New N-(Pyridine-2 -yl) Derivatives of 2-Azaspiro[4.4]nonane and. [4.5]decane-1,3-dione. Part II.
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11 4912 article
1-yl)-propyl]-3-methyl-3-phenyl- and 3-ethyl-3-methylpyrrolidine-2,5-dione derivatives as potential ... Methods: Anticonvulsant properties were evaluated in the maximal electroshock (MES), ... The compounds synthesized may be regarded as ... Physicochemical and spec- ...... properties of new N-pyridine-2-yl 3-substituted.
[ 2_326.pdf - Read/Download File

synthesis and anticonvulsant activity of new spirosuccinimides
The neurotoxic properties were determined ... The most active were N-(2- methoxyphenyl)- [V] and N-(4-chlorophenyl- ... N-(6-aminopyridin-2-yl)- [XII] 2- azaspiro[4.5]decane-1,3-diones, and the com- ... Synthesis and anticonvulsant activity of new spirosuccinimides differently ... Physicochemical data for compounds IV-XIX.
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Synthesis and Anticonvulsant Activity of Some - ImpactFactor
Jun 23, 2015 ... There is continuing demand for new anticonvulsant agents as it has not been ... substituted phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2H- ... properties. Clinical ... NH), 1679 (C=O), 1603 (C=N), 1574, 1481, 1455 (Ar. C=C) ..... Calculation of physicochemical parameters .... pyridine-4-carbohydrazides as.
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Crystal structure of 2-((2-chloropyridin-3-ylamino) methylene
Apr 2, 2016 ... Method A: a mixture of 3-amino-2-chloropyridine. (1.28 g, 0.01 mol), malononitrile (0.66 .... ndings led us to continue our work on the synthesis of biologically active ... A.; Maciag, D.: Synthesis, physicochemical and anticonvulsant properties of new N-. (pyridine-2-yl) derivatives of 2-azaspiro[4.4]nonane and.
[ ncrs-2015-0242.pdf?t:ac=j$002fncrs.2016.231.issue-3$002fncrs-2015-0242$002fncrs-2015-0242.xml - Read/Download File

GABA Modulating Agents: A Brief Review
Key words: Anticonvulsant agent synthesis, GABA nergics, epilepsy, seizures .... ( 4,5-0) pyridin-S-ol (THPO) and 5,6,7,S-tetrahydro-4H-isoxazolo [4,5-0] azepin- ..... (2006b) described the synthesis, physicochemical and pharmacological properties of new N-[(4-arylpiperazin-1-yl)-alkyl]-2-azaspiro[4.4]nonane- and ...
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Microwave assisted synthesis and pharmacological evaluation of
Some of the synthesized compounds were evaluated for their anticonvulsant ... ethylchloroacetate and anhydrous potassium carbonate in sufficient N ... yl] acetate and hydrazine hydrate 99% in sufficient ethanol (6-7 mL) was irradiated under .... Table 1: Physicochemical properties of 3,5-dicarboethoxy-1,4-dihydro-2  ...
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Synthesis and biological screening of some new substituted 2
anticonvulsant activity.4-7 In this study a new series of mercaptoquinazoline bearing iodine at the ... nitropyridine (0.005 mol) and potassium carbonate (2.0 g) in .... N-(1-Succinimido)-2-[3-(4-chlorophenyl)-4-oxo-6-iodo-3H-quinazolin-2-yl) thio]- ..... Table 1: The physiochemical properties of the new synthesized compounds.
[ Synthesis and biological screening of some new substituted 2 mercapto-4-(3h)-quinazolinone analogs as anticonvulsant agents.pdf - Read/Download File

Synthesis and Pharmacological Activities of Some New 3
Physalindicanols, new ... Synthesis and Pharmacological Activities of Substituted 1,2,4-Triazoles. In this study, various 3-β-[(N-benzenesulphonyl/tosyl)-4-(un) substituted anilino]ethyl-4-amino-5-mercapto-4(H)- ... physicochemical properties are enumerated in Table 1. ..... 4-amino-3-mercapto-5-pyridin-3'-yl-[1,2,4]triazole.
[ synthesis-and-pharmacological-activities-of-some-new-3substituted4amino5mercapto124triazoles.pdf - Read/Download File

Synthesis of some new antibacterial active cadmium and mercury
allylidene aminopropyl-imino)prop-1-ethyl)-N,N-dimethyl benzene amine ... of bioactivities, such as anticonvulsant (Sridhar et al.,. 2002) ... anticancer properties of ligands are enhanced after linking of Schiff base ... antibacterial activity of new Cd(II), Hg(II) complexes with substituted ... of 2,6-bis( benzimidazole-2-yl)pyridine.
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Full-Text PDF -
Aug 17, 2007 ... hydrazone [2], which were synthesized in our Department, have ... N. N NH2. O. H. Nifuroxazide. Isoniazid. Isonicotinic acid hydrazide .... new antiepileptic drugs have been introduced into clinical practice, the .... tested for their antimalarial properties. .... [5-(Pyridine-2-yl)-1,3,4-thiadiazole-2-yl]thio]acetic acid ...
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Synthesis and Quantitative Structure-Activity Relationships of
Aug 1, 1994 ... The synthesis of 2,3,6-triaminopyridine derivatives, representing a unique chemical structure ... analgesic, it exhibited potent antiepileptic properties ... N ,;1 °cH2cH3 ... in mind, new flupirtine analogs were designed in which .... Physicochemical Parameters and Biological Activities for Flupirtine Derivatives.
[ jm00045a005 - Read/Download File

A Highly Efficient Diversification of 2-Amino - ACS Publications
Nov 2, 2015 ... oral bioavailability drug properties as determine by using the Lipinski's Rule and ... support and Lee14 reported synthesis of 2-amido-1,3,4-.
[ acscombsci.5b00140 - Read/Download File

4-(1-Benzoyl-5-chloro-2-oxoindolin-3-ylideneamino)-N-(pyrimidin-2-yl) ... 2010), anticonvulsant (Siddiqui et al., 2011), anti-inflammatory (Nirmal et al., ... of chemical properties and the possibility to estimate the properties of new ... Physicochemical characteristics and anticancer activity of the synthesized isatin derivatives.
[ 1-s2.0-S1878535213000713-main.pdf?_tid=67e72504-562d-11e4-bd1b-00000aacb361&acdnat=1413571554_5ded3c766da88417c069c481395224b3 - Read/Download File

2 - methyl imidazo [1, 2 - International Journal of Pharmacy and
Jul 31, 2013 ... SYNTHESIS, DOCKING STUDIES AND BIOLOGICAL EVALUATION OF SOME NEWLY. SUBSTITUTED-5-(2 - METHYL IMIDAZO [1,2-a] PYRIDIN-3 -YL) -2,5 - DIHYDRO -1,3 ... activities of some new analogues of Imidazo [1, 2-a] pyridines. ... docking scores, possessed maximum anti-inflammatory property.
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benzimidazole derivatives – an overview - ijrpc
derivatives were synthesized with substitution of fluorine ... discover new chemotherapeutic agents to .... 2-(pyridin-2-yl)-N-(2-(4-nitrophenyl) pentan-3- .... anticonvulsant compounds have been ... physicochemical properties indicates that the.
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Download PDF - Springer
Feb 18, 2010 ... N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)hydrazinecarboxamide and B (1–3) ... anticonvulsant activity of the synthesized compounds was evaluated by MES .... We herein report the presence of a new steroid characterized as 24-methyl- cholesta-5-ene-3-ol- ..... because of their improved biological properties.
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Tetrazolium Compounds: Synthesis and Applications in Medicine
Mar 27, 2015 ... synthesized tetrazole derivatives (2-cyanophoric-5-phenyltetrazole) to 1950 ... pharmacological properties associated with substituted tetrazoles in the .... analgesic, anticancer, anticonvulsant, antihypertensive, .... results showed that N- (4-(2-(2H-tetrazol-5-yl)ethyl)-5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)-.
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Pyrrole: a resourceful small molecule in key medicinal hetero
compounds that contains a significant set of advantageous properties and .... physicochemical drug interactions, thermodynamics, heterocyclic ... molecule inhibitors, He et al. synthesized a new series of 2,5- ... dimethyl-N-(3-(1H-tetrazol- 5-yl)phenyl)pyrrole-3-carbaldehyde 17. ...... Antipsychotic and anticonvulsant activity. 2 ...
[ Pyrrole - a resourceful small molecule in key medicinal hetero-aromatics.pdf - Read/Download File

Recent advances - International Research Journal of Pharmacy
Feb 1, 2013 ... medicinal chemistry is necessary to consider physiochemical properties, used to develop new pharmacologically active .... Synthesis of 1H-quinazolinone 2,4 dione from 2-aminobenzonitrile with 3.0 equivalent of DBU in DMF was performed at ... N- (Pyrimidin-2- yl-benzenesulfonamide) quinazolin-. 4(3H)- ...
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