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Get PDF (530K) - Wiley Online Library
In vivo Retrovirus-mediated Herpes Simplex Virus Thymidine Kinase Gene. Therapy ... formed and tax-expressing rat T cell line TARS-1 with this retrovirus ( LNLTK virus), high levels of. HSV TK ... tax is capable of immortalizing human primary T cells” ” and rat ..... ing HTLV-I tax gene transduced by a retroviral vector: in.
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Cellular transformation by human T-cell leukemia virus type I
Human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that was isolated in 1980 from a ..... clusive expression of Tax in primary T-cells does not.
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Interaction of Retroviral Tax Oncoproteins With Tristetraprolin and
retroviruses, i.e., primate T-cell leukemia viruses and bo- ... Transduction, National Institute of Environmental Health Sciences, Research Trian- ... tax gene. Tax protein is a transcriptional activator of cellular gene expression .... for HTLV Tax-1 mutants were pTax2–58, pTax3–6, pTax3–8, ...... in primary rat embryo fibroblasts.
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Interleukin-2-Independent Pathway - Journal of Virology - American
Proliferative Response of Taxl-Transduced Primary Human. T Cells to ... Taxl, a protein encodedin the pX region of the HTLV-I genome ... gene expression are thought to lead to T-cell transformation. ... using a retroviral vector and compared the growth properties ... 1. trans activation of the Tax-responsive enhancer in Taxl -.
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Discordance between Bovine Leukemia Virus Tax Immortalization In
Rat primary T cells expressing HTLV-I tax gene transduced by a retroviral vector: in vitro and in vivo characterization. Int. J. Cancer 68:102–. 108. VOL. 74, 2000.
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Multiple Control Levels of Cell Proliferation by Human T-Cell
Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines: Possible ... Retroviruses, 10 (1994), pp. 1259– ... by human T-cell leukemia virus type I X- region genes transduced by a herpesvirus saimiri vector .... Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways.
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Molecular Mechanism of Tumorigenesis in Mice Transgenic for the
In tumor-derived cells, the expression of Tax led to an increased degradation ... Functional analysis of two long terminal repeats from the HTLV-I retrovirus ... primary T lymphocyte by HTLV-I X region genes transduced by a herpesvirus saimiri vector .... Type I human T cell leukemia virus Tax protein transforms rat fibroblasts ...
[ 1-s2.0-S0042682298992984-main.pdf?_tid=ae12eb1a-2857-11e5-b6e0-00000aacb361&acdnat=1436679455_d9bcadabff05c9c3f99d51f633dcc353 - Read/Download File

Efficient nonviral gene delivery into primary lymphocytes from rats
Jan 9, 2006 ... cells. In mice and rats, in vivo modulation of gene expression by ..... T cells expressing HTLV-I tax gene transduced by a retroviral vector: in vitro ...
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HTLV-2 Tax Immortalizes Human CD4 Memory T Lymphocytes by
Apr 30, 2012 ... -2) are two closely related retroviruses with the former causing ... Tax2 transformed rat fibroblast cells less efficiently than ... mary CD4 T Cells—The tax gene from HTLV-2 was fused with .... expressing primary CD4 T cells ceased growth in less than 4 ..... All tax2-gfp transduced T cells were able to grow.
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Human T‐cell leukemia virus type 1 Tax oncoprotein
Jan 17, 2015 ... Kyoto University, Kyoto, Japan; 8Center for Retrovirus Research, ... Adult T cell leukemia, BCL11B, HBZ, HTLV-1, Tax ... transduction of Tax in a human T-cell line repressed the expression of ... (1–3) Tax by itself immortalizes primary human ... tumor suppressor gene in T-cell acute lymphoblastic leukemia.
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Forum Rapid Letter Redox Events in HTLV-1 Tax-Induced Apoptotic
text of the contribution of Tax to HTLV-1-mediated T-cell im- mortalization and ATL ... regulating gene expression through activation of important .... formed Rat- 1 fibroblasts after serum starvation, and was .... cord blood T cells with tax using retroviral or Herpes virus .... Tax1-transduced primary human T cells to anti-CD3 anti-.
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HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing - Plos
Jan 6, 2016 ... The HTLV-1 bZIP factor (HBZ) gene, which is encoded in the minus strand of ... TIGIT was expressed on CD4+ T cells from HBZ-transgenic (HBZ-Tg) mice, and on ATL ... Blocking of TIGIT and PD-1 slightly increased anti-Tax. T-cell ..... (C) A retrovirus expressing HBZ or control retrovirus was transduced into.
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Human T Cell Leukemia Virus-I (HTLV-I) Tax-Mediated Apoptosis in
retrovirus to be causatively associated with human neo- plasia. A long-term ... A previous study using Jurkat T cells expressing a conditional ... optotic cell death in Tax-transformed Rat-1 fibroblasts after serum .... estradiol before CAT reporter gene assays were performed. A hor ..... Proliferative response of Tax1- transduced.
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human t-cell lymphotropic virus type 1 - IARC Monographs on the
retroviruses, HTLV-1 and STLV-1 induce T-cell neoplasms (Tsujimoto ... virus that contains regulatory genes (tax and rex) ... different animals, including rabbits, rats , mice, ... 5′LTR may control viral gene expression in vivo, .... latency period from primary infection until ATLL ..... The transduction of a pX-containing sequence.
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Role of Tax protein in human T-cell leukemia virus type-I - Springer
Tax modulates the expression of many viral and cellular genes through the ... by its ability to transform rodent fibroblasts and primary human T-cells and to ... Human T-cell leukemia virus type-I (HTLV-1) is the first discovered human retroviral ..... Many of them belong to the signal transduction and cytoskeleton pathways and ...
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15th International Conference on Human Retroviruses: HTLV and
Jun 6, 2011 ... in this model, serves as a readout for Tax gene expression and firefly luciferase driven by the ... infected CD4 T cells increased expression of HTLV-1 gene products [1]. ..... signaling events that characterize primary cancer cells were not conserved in vitro. .... Entry inhibition of human retroviruses in rat cells.
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Activation of cyclin D1 and D2 promoters by human T‐cell leukemia
Mar 26, 2002 ... formation of primary human T cells by HTLV-I. High expression ... HTLV-I infection to changes in cellular D-type cyclin gene ... HTLV-I is a retrovirus etiologically associated with ATL.1–3 .... versity, Tokyo, Japan) are subclones of Jurkat cells expressing Tax ..... forms rat fibroblasts via two distinct pathways.
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MULTIPLE VIRAL STRATEGIES OF HTLV-1 FOR - Annual Reviews
Feb 8, 2001 ... lar signals and are regulated downstream of signal transduction. .... primary CD4- positive T cells (27); transfection of a Tax-expressing vector ... as a trans-activator of viral gene expression responding to the 21-bp enhancer in the LTR (17, 16). Transcriptional regulation is the most critical step in retroviral.
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Examining Human T-Lymphotropic Virus Type 1 - NCI at Frederick
May 4, 2001 ... The retrovirus human T-cell leukemia virus type 1 ... infectivity and a tightly regulated gene expression program. In ... on the ability of HTLV-1 to infect and immortalize primary ... 9035) containing env, tax, and rex genes controlled by a CMV .... Recombinant HTLV-1 vectors transduce genes by cell-free.
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Human T cell leukemia virus type 1: the role of Tax in leukemogenesis
Aug 15, 2005 ... cellular gene expression and to functionally interfere with proteins involved in cell -cycle ... a complex retrovirus associated with two fatal human .... files of HTLV-1- infected cells and Tax-expressing ... the NF-κB family have been reported, the primary ... also immortalizes rat embryo fibroblasts and cooper-.
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