A Gene × Gene Interaction Between DRD2 and - ScholarWorks
Jun 22, 2007 ... Behavioral and Brain Functions 2007, 3:30 ... genes (CCK, CYP19, ESR1, and INS). In a similar vein,. Caspi et al ... that DRD2 had a statistically significant main effect on impulsivity, but ... polymorphisms that may also be implicated in the devel- opment of .... Racial differences in the dis- tribution of 7R ...
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Within-person variation in the postprandial lipemic response of
Jan 2, 2013 ... Background: The response to dietary fat plays a key role in met- abolic health. Although ... Results: The postprandial triacylglycerol response profile did not differ. (P = 0.64) ..... study suggests that such polymorphisms may also influence the ... tween lipemic response variation and cholecystokinin 1 receptor.
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Genetics and the placebo effect: the placebome - Gwern.net
makeup (a stable trait) influences clinical outcomes and potentially may ... potential placebo genetic biomarkers (the placebome) may not easily ... the role of mu opioid receptors in placebo analgesia was ... Single nucleotide polymorphisms (SNPs): sites in the genome that differ in the ... by race and/or ethnicity [48,49].
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related differences may account for some of the disparities found in weight gain among populations. ... Genetic and dietary influences on obesity at the present time. Obesity as a ... Thus, the interaction of functional gene polymorphisms with environmental factors may play a substantial role in the risk of developing obesity .
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Linkage Disequilibrium between Polymorphisms of ABCB1 and
May 23, 2013 ... The funders had no role in study design, data collection and analysis, decision to ... Drug resistance is known to be influenced by failure of drug transport ... other countries may be due to racial differences but after careful observation ..... Conceived and designed the experiments: SS CCK JPJ ZM. Performed ...
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Neurobiology - British Medical Bulletin
lucrative race for the ideal anti-obesity drug. Correspondence fo: Dr John ... functions may differ considerably. ... Neurotransmitters affecting food intake. A large ..... these receptors has allowed some clarification of the role of CCK in the regulation ..... there may be more minor polymorphisms in genes involved in body weight.
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Salt Sensitivity of Blood Pressure Is Associated With Polymorphisms
pressure (BP).1,2 Although universal consensus does not exist on the exact quantity of ... nucleotide polymorphisms (SNPs) of SLC4A5 have been .... Race was self- ... To control the influence that medications may play on the .... diet did not differ from that of low salt to high-salt diet (P=0.365). .... Cholecystokinin A receptor.
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genetic succeptibility to metabolic syndrome - IFCC
Slight differences include central obesity as the major feature and ... Race. Hispanics and Asians seem to be at greater risk for metabolic syndrome than other races are. ... Genetic factors could influence each individual component of the syndrome, and the syndrome itself. ... Polymorphisms in 8 genes were associated with.
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Association of haplotypes of inflammation‐related genes with gastric
May 3, 2000 ... differences exist in cancer rates, we aimed to evaluate the association ... locus may participate in mediating the susceptibility to gastric carcinogenesis and ... though the role played by other polymorphisms cannot be excluded. .... The influence of genetic variants in inflammation-related ...... Gastrin CCK,.
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A gene× gene interaction between DRD2 and DRD4 is associated
behavior were related to the dopamine D2 receptor polymorphism (DRD2) and the dopamine D4 ... Behavioral and Brain Functions 2007, 3:30 doi:10.1186/1744 -9081-3-30 ... that MAOA did not have a significant direct effect on crim- ... associated with ADHD may also be the same genes that .... Racial differences in the dis-.
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Download PDF - Plos
Jan 25, 2010 ... The observed differences in the expression profiles suggest a disease bias ... in Western populations, since gender did not play a role in PD ..... Epidemiological studies suggested that gender- and race-related genetic factors could influence the function of DA neurons and, .... cholecystokinin A receptor.
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SINGLE-GENE INFLUENCES ON BRAIN AND BEHAVIOR
the study of gene function in relation to brain and behavior. More than 7,000 ... targeted mutation with the capacity to disable it can be created. These knock- ..... nate forms (alleles) that create protein polymorphism, or individual differ- ences in .... is my belief that racial classifications of humans are scientifically indefensible.
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CISH and Susceptibility to Infectious Diseases - New England
Jun 3, 2010 ... published on May 19, 2010, at NEJM.org. ... When all five single-nucleotide polymorphisms (SNPs) (at positions −639, ... have a role in immunity against various infectious diseases. .... and race or ethnic group did not affect the de- .... no significant differences across the study populations for CISH −639,.
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Serotonin transporter gene polymorphism may be associated with
Jun 29, 2011 ... transporter gene linked polymorphic region (5-HTTLPR), was then evaluated, and ... suggest that 5-HTTLPR L allele may influence the susceptibility to PDS. ... TC of CCK-1 intron 1 , cyclooxygenase-1 T1676C , ... isms, and function [ 18]. .... controls) has a power of 80% to detect the assumed differ-.
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PDF(788K) - Wiley Online Library
such as for BMI in the absence of linkage to the AHI, may suggest that the study is ..... In each race, several loci appeared to influence AHI but not BMI; i.e., a ...
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PDF (404 KB) - ATS Journals
Feb 8, 2010 ... influenced by genes within pathways involved with obesity, cranio- ... Methods: A total of 1,080 single nucleotide polymorphisms (SNPs) .... Cholecystokinin A receptor ..... If replicated, such findings may suggest a role for antiin- ..... Racial differences in sleep-disordered breathing in African-Americans.
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Association of lipoprotein receptor, receptor.pdf
B, and LPL HindIII polymorphisms may not be associated with gallstone disease. © 2006 Elsevier ... genetic factors play an important role in pathogenesis of dis- ease [1–3]. ... ants, a silent base change affecting the 277th nucleotide in the first intron of ...... boh MI. Racial differences in the distribution of low density lipopro-.
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Jul 29, 2006 ... metabolize nicotine, as well as genetic differences in the psychological reward pathways that may influence individual ... polymorphisms in genes that are responsible for nicotine .... nicotine treated rats was accompanied by reduced CCK ... week, suggesting a role for CYP2A6 in nicotine tolerance.
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The Role of Genetic Variation across IL-1β, IL-2, IL-6 and BDNF in
Methods: Nineteen polymorphisms were genotyped using Taqman® assays in 188 ... Conclusions: SNPs across IL-1β and BDNF Val66Met may influence AIWG . ..... Race-and Treatment-Stratified Analyses . .... CCK: cholecystokinin ..... The variability in weight gain propensities between APs may be attributed to differences.
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Mitochondrial polymorphisms and dysfunction related to aggressive
with and may increase the susceptibility to AgP in the. Han Chinese ... a type of rare and severe periodontal disease, which affects systemically ... microbial plaque is unique in each case, leading to differ- ences in the ... The possible role of CTSC variants differs .... DMEM with 10% FBS containing 10 ll of CCK-8 solution to ...
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