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Polymer Vesicles with a Red Cell-like Surface Charge
Dec 1, 2009 ... Polymer Vesicles with a Red Cell-like Surface. Charge: Microvascular Imaging and in vivo. Tracking with Near-Infrared Fluorescence a.
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full CV - SEAS - University of Pennsylvania
Blood Circulation some novel polymer Vesicles and Filaments (we called ... motivated us to study and exploit how Cells are recognized as 'Self' versus ' Foreign' by ...... Surface probe measurements of the elasticity of sectioned tissue and ..... charge: Microvascular imaging and in vivo tracking with near infrared fluorescence.
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Red Blood Cell: Membrane and Metabolism Responses to
Oct 1, 2013 ... red blood cells (RBC)- membrane interaction with different nanoobjects. One such .... Another study, dedicated to bio-polymers, such as branched .... development of lipid vesicles-constructed artificial RBC and went up to .... Vesicles with a Red Cell‐like Surface Charge: Microvascular Imaging and in vivo.
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Targeted siRNA delivery to diseased microvascular endothelial
used nonviral lipid and polymer-based siRNA delivery systems. ... Keywords drug delivery; siRNA; endothelial cells; liposomes; tar- ... tegral part of the impermeable blood brain barrier, whereas liver ..... half-life, the surface charge can be masked by covering the car- .... the endocytic vesicles of the endothelial cells (65).
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Get PDF (339K) - Wiley Online Library
Jun 30, 2004 ... lipid of lower surface charge density (DOTAP instead of. DC-chol) led ... the strong affinity of delivery systems for the tumor cells and the efficient ...
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Uptake of poly (2-hydroxypropylmethacrylamide)-coated gold
May 2, 2013 ... coated gold nanoparticles in microvascular endothelial cells and transport across the blood–brain barrier† ... surface charge.10,11 In vitro studies demonstrated that primary ... nanoparticles with different neutral-charged polymer shells ..... vesicle-like structures that were not freely located in the cyto- plasm ...
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Delivering nanomedicine to solid tumors
Sep 14, 2010 ... ization of tumors using innovative imaging techniques, ... and transendothelial channels formed by vesicles,24,25 and ... blood cells (rBCs) in tumor vessels can be an order of mag- ..... of the particle is similar to that in water. the two-phase ..... particles.105,106 as the surface charge becomes larger (either.
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Targeted pharmaceutical nanocarriers for cancer therapy and imaging
Feb 12, 2007 ... circulation in the blood 8,9 and ability to accumulate in vari- ... vesicles that vary in size from 50 to 1000 nm and can be ... helps a drug molecule to penetrate a cell membrane and ... surface with synthetic polymers and appropriate ligands, ... vents opsonization include shielding of the surface charge,.
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Differential uptake of nanoparticles by endothelial cells through
Feb 25, 2014 ... charge and lipophilic characteristics of an NP surface offers a general means of ... targeting motifs like antibodies or short peptides that exhibit high affinity toward ... cluding endothelial cells that form the blood vessels. Devel- ... bear sulfonate- containing polymers, lipid NPs that are prefer- entially taken up ...
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Dextran and Polymer Polyethylene Glycol (PEG) Coating Reduce
May 9, 2012 ... Endothelial cells took up nanoparticles of all sizes and coatings in a dose ... resonance imaging [2], magnetic hyperthermia [3], and cell labeling and ... Nanoparticle size, in addition to structure and surface coating, ... which green = live cells and red = dead cells; and (B) Quantification of .... Similar to 2D.
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PDF Full-text - MDPI
Jun 25, 2016 ... including deoxyribonucleic acids (DNA), proteins, or imaging agents [2,3]. The use of ... drug delivery applications and their interaction with cells. ... Liposomes and vesicle-like nanocarriers are hollow spherical structures formed by the .... Most liposome nanocarriers carry some surface charge in aqueous ...
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PDF (4477 KB) - Future Medicine
Mar 16, 2016 ... Keywords: blood–brain barrier • brain • drug delivery • imaging .... Polymers are macromolecules having large chains con- taining a ... Liposomes are vesicles composed of one (unilamel- ... of human brain-microvascular endothelial cells, which ..... charge of the functional groups present at the surface,.
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Factors Affecting the Clearance and Biodistribution of Polymeric
Aug 4, 2008 ... modifications (pegylation and surface charge), and finally, targeting ligand functionalization. All ... cases, target tissues or specific cell surface antigens with a ... approaches to improving nanoparticle blood residence and ..... could exhibit flexibility similar to that of free PEG polymer ...... in vivo imaging. Proc.
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Hi-Res PDF - ACS Publications - American Chemical Society
nanoparticles aiding in medical imaging, recognizing cancers, and delivering ... cancer cells and on designing biocompatible charged gold nanoparticle (AuNP) ..... patients is due to the rough surface of the tumor and long finger-like .... signaling results in the disruption of blood vessel growth, microvascular leakage,.
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Here - NANOinBIO 2016
May 31, 2016 ... Alexander Dulebo: High-Resolution Imaging of Living Cells by Atomic ... Dominika Hobernik: Surface modified dextran nanoparticles as ... Jean- Sébastien Thomann: Anti-biofouling Properties in Blood of ... polymers with bone- like strength ... David Duday: Degradation of small unilamellar vesicles and their  ...
[ NANOinBIO_2016_Book_of_Abstracts.pdf - Read/Download File

The plasma protein fibrinogen stabilizes clusters of red blood cells in
Mar 11, 2014 ... Research Centre for Molecular Imaging and Screening, School of ... proteins such as fibrinogen cause red blood cells to form large ... fibrinogen or the synthetic polymer dextran leads to an enhanced ... ability14,15 and surface charge16. ... descriptions of the flow of blood or suspensions of vesicles in ...
[ Clusters.pdf - Read/Download File

Localization of sterically stabilized liposomes in Klebsiella
For a rational optimization of liposome localization, the blood clearance kinetics ... particle size, bilayer fluidity or surface charge were studied in a rat model of a ... to be a direct consequence of the presence of the polymer coating operating as a ... The use of a drug carrier, like liposomes, could help to improve the efficacy of  ...
[ 1-s2.0-S000527369900139X-main.pdf?_tid=c75f7724-4242-11e4-b6b0-00000aab0f02&acdnat=1411381710_566abdc9671c8650bbf6b914b8a2d5fb - Read/Download File

Superparamagnetic core/shell GoldMag nanoparticles: size
Mar 25, 2015 ... Additionally, nanoparticles are smaller than a cell, protein or gene, which has led to ... In previous studies, GMNPs have been applied to MR imaging and other ..... (A) Relative number of tube-like structures formed from HUVECs labeled ... the nanoparticle size, shape, surface coating, and surface charge.
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Transendothelial Transport of Serum Albumin - The Journal of Cell
between blood radioactivity and vascular labeling den- sity was found, with a ... endothelial cell surface were proposed as key elements in vascular permeability  ...
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Endothelial targeting of high-affinity multivalent polymer
Feb 27, 2006 ... ICAM-directed endothelial targeting of polymer nanocarriers ... higher EC affinity vs naked anti-ICAM (Kd ~80 pM vs ~8 nM) in cell culture, and, likely ..... Blood clearance reflects uptake of anti-ICAM/PNC and IgG/PNCs in the ... PNC diameter of 120 nm and surface charge -19.5±3.3 mV, similar to prototype.
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