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Performance of HIV-1 Drug Resistance Testing at Low Level
Jan 14, 2014 ... genotypic sensitivity score (GSS) was calculated based on therapy and ... However, despite stable ART, many patients ... antiretroviral resistance during low-level viraemia on patients ... We evaluated genotype success rates of all HIV- infected adults who ..... Persistent Low-level Viremia Is Associated with.
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Low-level viremia persists for at least 7 years in patients on
Mar 11, 2008 ... on antiretroviral therapy despite suppression of plasma RNA to. <50 copies per ml, ... These data suggest that low-level persistent viremia appears to arise ..... showing that viremia persists in patients on successful therapy, for up to 3 ..... inferential tools for virological data from AIDS clinical trials. Biometrics ...
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Significance and clinical management of persistent low level viremia
Apr 14, 2014 ... Running title: Persistent low level HIV-1 viremia ... Combination antiretroviral therapy (cART) is the cornerstone of HIV-1 treatment. ... on “successful” cART (4, 5), but most of these patients harbor plasma HIV-1 RNA that ..... Critically, despite the potential genotyping success at lower strata of LLV, there is a.
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Persistent HIV Viremia: Description of a Cohort of HIV Infected
Dec 22, 2015 ... Abstract: The introduction of antiretroviral therapy (ART) has ... who continue to have significant detectable viral load despite ART [8 ... according to sociodemographic variables, HIV risk factors, presence of comorbid clinical conditions, ..... Low-Level Viremia in a Cohort of HIV-Positive Patients: Results from ...
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Persistent HIV-1 replication during antiretroviral therapy
persistent low-level spread of the virus to uninfected cells (replication). The success in curing HIV will ... persistent HIV replication could have clinical consequences and might limit the efficacy of .... RNA being successfully reversed transcribed (despite ..... HIV-1 viremia in patients on highly active antiretroviral therapy.
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HIV Drug Resistance Profiles and Clinical Outcomes in Patients with
Keywords: HIV; Low Level Viremia; Treatment Experienced Patients; HIV Drug ... Combination antiretroviral therapy (ART) has lead to dra- ... certainties remain regarding the significance of persistent low level ... trol of LLV, despite accumulation of DR mutations, sug- .... intensification was successful in 18/24 (75 %) and 5/16.
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A brief history of antiretroviral therapy of HIV infection: success and
Key words: HIV, antiretroviral therapy, eradication. Riassunto (Una ... Despite these unquestioned successes, the problem is far from .... clinical efficacy but on their effect on plasma HIV .... trolled, chronic low-level viremia and inflammation.
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Association between discordant immunological response to highly
active anti-retroviral therapy, regulatory T cell percentage, immune cell activation and very low-level viraemia in HIV-infected patients ... nomenon may persist despite, sustained anti-retroviral therapy and ... [17,18], immunological suboptimal gain [18] or persistent ... HAART for at least 1year (virological success , VL < 50.
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Original article Clinical significance of transient HIV type-1 viraemia
bination antiretroviral therapy (cART). We studied the ... not low-level, viraemia are strongly associated with clinical outcome ... treatment with combination antiretroviral therapy ... Persistent low-level viraemia ...... interruptions of successful antiretroviral treatment. ... replication-competent HIV despite prolonged suppression.
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Impact of a decade of successful antiretroviral therapy - eLife
It persists despite suppressed viremia in patients undergoing effective ... The mechanisms underlying HIV-1 persistence have not been fully elucidated ... Low levels of viral reservoirs have been associated with an absence of viral rebound after treat ... Early treatment initiation with ART will likely become the standard clinical ...
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Incomplete Viral Suppression Under Potent Antiretroviral Therapy
therapy remains common in clinical practice ... els of viremia, it is clearly preferable to achieve and ... persistent activity of some drugs against resistant ... low and stable plasma HIV-1 RNA level despite the .... Perspective - Incomplete Viral Suppression Under Antiretroviral Therapy ... patients despite the emergence of drug-.
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Intensification of Antiretroviral Therapy with a CCR5 Antagonist in
chronically HIV-1-infected patients receiving antiretroviral therapy. Methods: ... is only detectable using ultrasensitive assays, can persist despite. ART [2–4]. The origin and clinical implications of persistent low- level viremia are uncertain. While some ... cells and could prove helpful in monitoring the success of therapeutic ...
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Clinical relevance of genotypic resistance testing today
Mar 5, 2016 ... of virologic success (Zaccarelli et al. AIDS 2005). For these ... Indeed, during antiretroviral therapy, many patients have episodes of low-level viremia (50-1000 copies/mL) that ... Despite genetic variability between different HIV-1 sub- .... and clinical management of persistent low level viremia and very low.
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Potential Implication of Residual Viremia in Patients on Effective
The current antiretroviral therapy (ART) has suppressed viremia to below the limit of detection of clinical viral ... Plasma HIV-1 loads persist at extremely low levels below the clinical detection limit. .... results in persistent residual viremia during therapy.10,28 In ..... Despite a minimum of a three log10 reduction in reservoir.
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Rate and Determinants of Residual Viremia in Multidrug
Residual HIV viremia, defined by low levels of plasma HIV RNA with enhanced- sensitivity assays, may persist even in the presence of successful antiretroviral therapy, but little is known about its ... cation is likely to have clinical relevance, because low-level ... creased risk of virological failure, drug resistance, and chronic.
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cART
The goal of combination antiretroviral therapy (cART) is to suppress HIV ... of pVL has emerged as the primary determinant of treatment success.1,2 The target pVL ... interpret and manage very low-level viremia (VLLV) of 20 to 50 cpm detected with ... What clinical issues have arisen in the era of real time HIV PCR testing?
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From reactivation of latent HIV1 to elimination of the latent reservoir
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 ... low level of residual viremia can be consistently detected by ultrasensitive ... Despite its great success, lifelong. HAART can .... mentioned clinical studies on patient plasma virus levels. ... the correlation between HIV-1 persistence and the latent viral.
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HIV-1 Residual Viremia Correlates with Persistent T-Cell - Plos
Oct 30, 2009 ... Background: The clinical significance and cellular sources of residual human ... production despite suppressive combination antiretroviral therapy (cART) ... significance of persistent low-level viremia below 50 copies per ml ...... protease evolution in HIV-1-infected patients after 2 years of successful highly.
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Blips and its clinical relevance in HIV Patients on Treatment
Blips should not be confused with persistent low-level viremia, which is usually ... Despite fully active antiretroviral therapy, low-level viremia ..... A similar study of 272 patients on successful antiretroviral therapy demonstrated that blips may.
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Obstacles to successful antiretroviral treatment of HIV-1 - medIND
adherence to therapy, low levels of continued viral replication in cellular reservoirs and augmentation of host ... Despite this increased ... the majority of all antiretroviral drugs in clinical practice .... ongoing viraemia there is a progressive accumulation of .... are persistent virus replication and immunologic decline, which.
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