Management of chemotherapy-associated hepatotoxicity in
Mar 10, 2009 ... effects of these drugs on outcome after hepatic resection. In this Review, we outline the rationale for the use of perioperative chemotherapy for colorectal liver metastases, associations between specific agents and patterns of liver injury, and ... For patients with stage IV colorectal cancer confined to the liver ...
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Chemotherapy-Associated Liver Injury: Impact on Surgical
Jul 20, 2010 ... Chemotherapy is integral to the treatment of colorectal cancer liver ..... Five-year survival after resection of hepatic metastases from colorectal cancer in .... T. Patterns of hepatotoxicity after chemotherapy for colorectal cancer ...
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Download as a PDF - CiteSeerX
Colorectal cancer • Liver metastases • Chemotherapy • Targeted agents • Hepatic ... when the treatment is given both before and after surgery. .... distinct nodularity consistent with sinusoidal centrolobular congestion characteristic of oxaliplatin hepatotoxicity. .... ated with a broader pattern of parenchymal hepatic injury,.
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Role of Adjuvant Therapy After Resection of Colorectal Cancer Liver
May 1, 2010 ... chemotherapy after resection of liver- confined metastatic colorectal cancer. Optimal regimens and ... the colon to the liver may explain this pattern of metastatic ...... ment of chemotherapy-associated hepatotoxicity in colorectal ...
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Chemotherapy-Associated Liver Injury in Patients with Colorectal
Jul 6, 2012 ... metastatic colorectal cancer entered into phase III trials rise from 6 to 12 ...... Gruenberger T. Patterns of hepatotoxicity after chemotherapy for.
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Sinusoidal obstruction syndrome after oxaliplatin-based chemotherapy
“blue liver syndrome”, is a commonly recognized vascular pattern of drug- induced ... tin-based preoperative chemotherapy for colorectal cancer liver metastasis ...
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The association between preoperative chemotherapy and the
and mortality. Aim: To evaluate the prevalence of hepatic steatosis in patients undergoing preoperative chemotherapy for metastatic colorectal cancer. ... The predominant histological pattern of the cell damage was steatosis, which was detected in 51% of the ... after vascular exclusions such as the Pringle maneuver, which.
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Full Text (PDF) - Proceedings of the National Academy of Sciences
Aug 27, 2013 ... model successfully predicts extent of tumor kill after chemotherapy. (R2 = 0.7– 0.91). ... of patients with colorectal cancer metastatic to liver, and demon- ...... ( 2008) Patterns of hepatotoxicity after chemotherapy for colorectal.
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Histological study of the effect of 5-Fluorouracil on normal liver and
FU LD50 on liver and kidney of healthy mice and to show if these changes are irreversible or not after stopping the ... Chemotherapy is the use of cytotoxic drugs to control or eliminate cancer. ..... F. Wrba, B. Gruenberger and T. Gruenberger Patterns of hepatotoxicity after chemotherapy for colorectal cancer liver metastases.
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Update on the Role of Imaging in Management of Metastatic - RSNA
Evolution in the treatment of metastatic colorectal cancer (mCRC) has led to ... by oncologists when the liver is the only site of metastatic disease. Unresectable ... of unusual response patterns, as well as of complications and toxici- .... after chemotherapy (14). Some of the ...... Hepatotoxicity (hepatic steatosis, steatohepa -.
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Article (Published version) - Archive ouverte UNIGE
Chemotherapy-related hepatic sinusoidal obstruction syndrome ... ectal liver metastases (CRLM; refs. 1–3). ... Cancer Therapeutics Online (http://mct. aacrjournals.org/). ...... berger T. Patterns of hepatotoxicity after chemotherapy for colorectal.
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Severe hepatic sinusoidal obstruction associated with oxaliplatin
based chemotherapy in patients with metastatic colorectal cancer. L. Rubbia- Brandt1*, V. ... Sinusoidal injury persisted several months after end of chemotherapy, and fibrosis may ..... Only the hepatotoxic effects of 5-FU have received much ... hepatic regeneration, which reached a pattern of NRH in seven cases. NRH has ...
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Hepatotoxicity Secondary to Chemotherapy
recovery after injury,1 and in preparation for chemotherapy, oncologists need ... Keywords: Hepatotoxicity; Drugs; Cancer; Chemotherapy; Liver. Abbreviations: ...
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Pathological Complete Remission in Young Colon Cancer Patient
sion of large hepatic metastasis after palliative chemotherapy in combination with bevacizumab is presented. ... Keywords: Metastatic Colorectal Cancer; Pathological Complete Remission; Bevacizumab. 1. .... grade 1 hepatotoxicity was observed during treatment .... Analysis of Recurrence Patterns and Prognostic Factors.
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Treatment of multi‐focal colorectal carcinoma metastatic to the liver
Dec 17, 2004 ... Key words: colorectal cancer; liver metastasis; oncolytic virus; vesic- ular stomatitis ... chemotherapy, several groups have investigated the potential of hepatic arterial .... Absence of significant hepatotoxicity after hepatic artery infusion of ... the cause of death and dissemination pattern of the tumor. Control.
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Yttrium-90 radioembolization of hepatic metastases from colorectal
Jul 25, 2014 ... Liver metastases from colorectal cancer (CRC) result in substantial ... The primary treatment is systemic chemotherapy, and in selected .... PET scan (B) obtained 6 weeks after Y-90 therapy shows no FDG ... required) to assess the hepatic uptake pattern of the microspheres. .... of Grade 3 hepatotoxicity.
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Biochemical Parameters for Longitudinal Monitoring of Liver - Plos
Jun 18, 2013 ... Results: Following MCD diet, but not after FOLFOX chemotherapy treatment, .... treatment of colorectal liver metastases , 5-fluoro-uracil (5-FU) ..... Patterns of hepatotoxicity after chemotherapy for colorectal cancer liver.
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PDF (165 KB) - HPB
1Division of Cancer Surgery, 2Department of Pathology, and 3Division of Cancer Medicine, Peter ... There were no further associations between injury patterns and target ... colorectal metastases < liver, chemotherapy < liver, basic science < liver ... after a major hepatic resection.8–10 Steatohepatitis is also clearly.
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Bone Marrow-Derived Mesenchymal Stem Cells Promote Hepatic
Apr 23, 2013 ... mal stem cells (MSCs) to stimulate liver regeneration after partial hepatectomy in rats. ..... F, Gruenberger B, Gruenberger T: Patterns of hepatotoxicity after chemotherapy for colorectal cancer liver metastases . Eur J Surg.
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STIVARGA (regorafenib) Label - U.S. Food and Drug Administration
metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti- .... After recovery of any Grade 3 or 4 adverse reaction at the 120 mg dose (except ... hepatotoxicity as manifested by elevated liver function tests or hepatocellular necrosis ...
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