The mammalian nonsense-mediated mRNA decay pathway: To
Feb 4, 2009 ... Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination codons (PTCs). Although the core ...
[ 1-s2.0-S0014579309000155-main.pdf?_tid=bf3019f2-1f31-11e4-97e9-00000aab0f6c&acdnat=1407526105_5c0914e378b4a23f909188e469e0b22a - Read/Download File
Nonsense-mediated mRNA decay in humans at a glance
Nonsense-mediated mRNA decay (NMD) is an mRNA quality-control mechanism ... different 5′-cap-binding proteins typify mRNAs undergoing NMD? How can ...
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Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome
Jun 2, 2016 ... Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality ... protein synthesis and mRNA quality inspection via NMD, a pro-.
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Nonsense-mediated mRNA decay factors act in - Ivica Letunic
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that ... proteins act mainly in the NMD pathway and their role in mRNA decay has not ...
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The Coupling of Alternative Splicing and Nonsense‑Mediated
by the nonsense‑mediated mRNA decay (NMD) pathway. ... may link alternative splicing and NMD to regulate the abundance of mRNA transcripts. This.
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Nonsense-Mediated mRNA Decay: Degradation of Defective
Oct 2, 2015 ... Abstract. Nonsense-mediated mRNA decay (NMD) is a eukaryotic surveillance mech- anism that monitors cytoplasmic mRNA translation and ...
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Nonsense-mediated mRNA decay - Biochemical Society Transactions
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense- mediated mRNA decay). NMD is a mechanism that ...
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Regulation of Natural mRNAs by the Nonsense-Mediated mRNA
The nonsense-mediated mRNA decay (NMD) pathway is a specialized mRNA degradation pathway that degrades select mRNAs. This pathway is conserved in ...
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Nonsense-mediated mRNA decay: novel mechanistic insights and
Nonsense-mediated mRNA decay (NMD) was originally coined to define a qual- ... according to which NMD ensues on mRNAs that fail to terminate translation.
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SURVEY AND SUMMARY Mechanism and regulation of the
Jan 14, 2016 ... The Nonsense-mediated mRNA decay (NMD) path- way selectively degrades mRNAs harboring prema- ture termination codons (PTCs) but ...
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Nonsense Mediated mRNA Decay (NMD) Mechanism in Drosophila
Abstract: Nonsense-mediated mRNA decay (NMD) is a mechanism that prevents the accumulation ... mechanism is involved in the rapid degradation of mRNA.
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Nonsense-mediated mRNA decay - Case Western Reserve University
DSE downstream sequence element. EJC exon–exon junction complex. mRNP messenger ribonucleoprotein particle. NMD nonsense-mediated mRNA decay.
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Nonsense-mediated mRNA Decay - Cold Spring Harbor Symposia
Nonsense-mediated mRNA decay (NMD), also called. mRNA surveillance, is ... human (h) Upf proteins known to function in NMD, and we use this information to ...
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New insights into the formation of active nonsense- mediated decay
In the nonsense-mediated mRNA decay (NMD) path- way, an exon-junction protein complex (EJC) and hUpf proteins mediate rapid downregulation of aberrant.
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No Nonsense: The Protection of Wild-Type mRNAs From Nonsense
Apr 8, 2016 ... mRNAs From Nonsense-Mediated mRNA Decay ... Wild-type mRNAs with NMD- targeting signals, which include 1) a translated uORF, 2) a.
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Nonsense-mediated mRNA decay modulates clinical - Nature
Jun 7, 2006 ... The nonsense-mediated decay (NMD) pathway is an mRNA surveillance system that ... eliminates NMD and prevents the normally rapid decay.
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Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated
May 5, 2016 ... PERSPECTIVE. Spermatogenesis Studies Reveal a Distinct. Nonsense- Mediated mRNA Decay (NMD). Mechanism for mRNAs with Long 3. 0.
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Chapter 5 Nonsense-mediated mRNA decay is a regulator of - FTP
furthering our understanding of nonsense-mediated mRNA decay (NMD). ... exons that lead to NMD-targeting on inclusion (Lareau et al., 2007; Ni et al., 2007 ;.
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Stop that nonsense! | eLife
Sep 9, 2014 ... MicroRNA-mediated repression of nonsense mRNAs. ... cells have evolved methods known as nonsense-mediated decay (or NMD for short) to ...
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Nonsense-mediated decay: linking a basic cellular process to
mechanisms, among which nonsense- mediated decay (NMD) is perhaps the best studied. NMD ensures destruction of mRNAs that harbor premature ter-.
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