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rFVII for Pediatric Acute Intracranial Hemorrhage
We report on a case of acute intracranial hemorrhage in a newborn with congenital factor VII deficiency treated with. rFVIIa and given a prophylactic program ...
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Factor VII Deficiency
Factor VII Deficiency: An Inherited Bleeding Disorder. ...... 1) Ariffin, H.; Lin, H.P. Neonatal intracranial hemorrhage secondary to congenital factor VII deficiency:.
[ engVII.pdf - Read/Download File

Neonatal Coagulation Disorders
BACKGROUND AND PATHOPHYSIOLOGY: Neonatal bleeding results from disorders of platelets ... A. Congenital factor deficiencies: •X-linked ... •Autosomal recessive (rare): Factors V, VII, X, XI, XII, XIII, afibrinogenemia ... A. Disseminated Intravascular Coagulation (DIC) occurs secondary to ... intracranial hemorrhage.
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Successful prophylaxis against intracranial hemorrhage using
V splice site mutation associated with severe factor V deficiency. Blood. 2002; 99: ... weekly administration of activated recombinant factor VII in a newborn with severe factor VII deficiency. J Thromb ... showed that the administration of rFVIIa as a secondary ... and factor VII genotype in congenital factor VII deficiency. Thromb.
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Jaundice and factor VII deficiency in newborn
But in intracranial hemorrhage (ICH) jaundice is rare or ... This case is a rare presentation of factor VII deficiency which referred for jaundice secondary to ICH in newborn period. Case report ... complication in newborns with congenital FVII.
[ article_1753_cfb84d597f59665165ccd3d79487ba3c.pdf - Read/Download File

Factor V deficiency: a concise review - National Hemophilia
bleeding, but overall, FV-deficient patients appear to have a less severe .... 25 exons, and is transcribed into a nearly 7-kb long ..... Factor V inhibitor in neonatal intracranial hemorrhage secondary to severe congenital factor V deficiency.
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Rare Bleeding Disorder Registry: deficiencies of factors II, V, VII, X
Rare Bleeding Disorder Registry: deficiencies of factors II, V, VII,. X, XIII ... deficiencyarethemostfrequentcongenitalbleedingdisorderswith .... those with FII < 0.01 U mLÀ1, 20% had intracranial bleeds. ..... secondary to homozygous FVII deficiency following birth .... a high degree of embryonic lethality, with early neonatal intra-.
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Prenatal Exclusion of Severe Factor VII Deficiency
their newborn children died of massive intracranial hemorrhage secondary to severe congenital FVII deficiency. Complete se- quence analysis of the factor VII  ...
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NovoSeven Coagulation Factor VIIa - U.S. Food and Drug
is recombinant human coagulation Factor VIIa (rFVIIa), intended for ... Recombinant FVII is secreted into the culture media (containing newborn calf .... Single dose pharmacokinetics of NovoSeven in congenital Factor VII deficiency, at doses of 15 ... patient died of AIDS and the other of intracranial hemorrhage secondary to ...
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Bleeding Prophylaxis in a Child With Cleft Palate and Factor VII
KEY WORDS: bleeding prophylaxis, cleft palate, factor VII deficiency ... Associations between cleft palate and other congenital coagulation disorders such as ..... intracranial haemorrhage in severe neonatal FVII deficiency. Haemophilia. 2000 ...
[ 04-165.1 - Read/Download File

Intracranial Hemorrhage in Term Newborns: Management and
must be distinguish from secondary intraparenchymal ... ment intracranial hemorrhage in a single term newborn is shown in Figure 1. ... [7] reported primary subarachnoid hemorrhage as the ..... to coagulation factor deficiency) have been implicated in newborns ... such as hypoxia, congenital heart disease, extracorporeal.
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Congenital factor X deficiency - An unusual cause of Intracranial
Congenital factor X deficiency is a rare autosomal recessive disorder that ... On examination the neonate was markedly pale with active bleeding. ... its active form as a serine protease both by factor VII and calcium, with tissue ... anticoagulant therapy, liver disease, Vitamin deficiency and secondary to drugs like phenytoin.
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A neonatal presentation of factor V deficiency: A case report
Feb 21, 2007 ... first presentation of a congenital bleeding disorder. In cases of factor V ... festation of factor V deficiency in the neonatal period. It preceded an ...
[ 1471-2431-7-8.pdf - Read/Download File

PDF (690.32 KB) - KoreaMed Synapse
Intracranial hemorrhage in term or late preterm ... Key Words: Hemostasis, Newborn, Hemorrhage, Congenital bleeding disorder, .... Newborns with thrombocytopenia secondary to .... deficiency25), factor VII deficiency with hydrocephalus and.
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Management of Pregnancy in a Chilean Patient with Congenital
Nov 14, 2014 ... Congenital Deficiency of Factor VII and Glanzmann's ... Patients with inherited bleeding disorders are rare in obstetric practice ... the neonatal management of a possibly affected fetus. .... hemorrhage occurred in 34% and secondary postpartum .... hemoperitoneum and intracranial hemorrhage: report of a.
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Perinatal management of newborns with haemophilia
philia A (F VIII deficiency) and 15±20% are haemophilia B. (F IX deficiency). .... range 31´3±54´5 s), secondary to physiologically low levels of vitamin K- dependent clotting factors (F II, F VII, F IX and F X). ... intracranial haemorrhage ( ICH) in nearly 600 000 term ..... of a congenital coagulation disorder in a newborn and often.
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5 treatment of specific hemorrhages - Wfh.org
7. Following a joint bleed, flexion is usually the most comfortable position, and any attempt to change this position causes more pain. 8. Secondary muscle spasm follows as the patient tries ..... Intracranial hemorrhage in children with congenital factor deficiencies. ... neonatal period--the role of CT imageing in suspected.
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Diagnostic and Therapeutic Challenges of Intracranial Hemorrhage
... Hemorrhage in. Neonates With Congenital Hemophilia: A Case Report and Review ... Intracranial hemorrhage (ICH) in full-term neonates with ... intensive factor replacement therapy that the patient needs is ... herniation secondary to edema and mass effect.10,11 .... ing deficiencies.23 These findings strongly suggest.
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Bleeding and Thrombosis Issues in Pediatric Patients - Karger
... of infants with se- vere coagulation factor deficiencies may present with in- ... Bleeding time is shorter in healthy neonates as compared to adults ... Google. 66.249.65.22 - 7/6/2016 7:43:02 AM ... Prenatal diagnosis of most severe congenital factor de- ficiencies is ... emic stroke and cerebral venous thrombosis in children.
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Comparative Effectiveness Review - AHRQ Effective Health Care
Search 2: FACTOR VIIa AND Intracranial Hemorrhage NOT Animal-only. Studies .... A or B or factor. VII deficiency (congenital ... Journal of Maternal-Fetal & Neonatal. Medicine 2007 ...... and primary/secondary prophylaxis. Best Pract Res Clin ...
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