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NAD+ analogs substituted in the purine base as substrates for poly
Abstract. Poly(ADP-ribosyl) transferase (pADPRT) catalyzes the transfer of the ADP-ribose moiety from NAD+ onto proteins as well as onto protein-bound ...
[ 1-s2.0-S0014579396011374-main.pdf?_tid=7eb2a91c-6a90-11e4-94a1-00000aab0f6c&acdnat=1415813136_26f0181f0ccc3debdd6908720c7c361b - Read/Download File

PDF (485.5KB) - Wiley Online Library
NAD + analogs substituted in the purine base as substrates for ... the transfer of the ADP-ribose moiety from NAD ÷ onto proteins as well as onto protein-bound ...
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Substituted Nicotinamide Analogues of Nicotinamide Adenine
... analogues have been prepared in which the purine, pyridine, and ribose moieties have been modified (2-12). ... properties of some substituted nicotinamide analogues. Data ... Enzymes and Coenzymes-NAD and NADH were products of.
[ 2823.full.pdf - Read/Download File

Design, Synthesis and SAR Studies of NAD Analogues as Potent
Sep 29, 2014 ... (ara-F NAD), a series of NAD analogues were synthesized and their ... three moieties of NAD, i.e., nicotinamide nucleoside, pyrophosphate and .... with C-2 or C-6 substituted purines, i.e., ara-F NHD (12), ara-F NGD (13) and ...
[ eb64c4281ba4d93760ccf7f129effe53ca57.pdf - Read/Download File

Effect of gangliosides and substrate analogues on the hydrolysis of
diphtheria toxin, analogues of NAD were inhibitory, adenine being the ... toxin, water serves as an acceptor for the ADP-ribose moiety of. NAD in lieu of the ...
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Potent Inhibitors of Human Inosine Monophosphate Dehydrogenase
Mar 1, 1995 ... Fluorine-Substituted Analogues of Thiazole-4-carboxamide Adenine. Dinucleotide1 .... thesis of NAD analogues (70-80% yield) by modification.
[ jm00007a007 - Read/Download File

Enzymatic Properties of 8-Bromoadenine - ACS Publications
of the base to the ribose moiety. It is generally agreed ... 8-Substituted purine nucleotides occupy a special place among ... and anti conformers of 8-substituted ATP analogues, including .... NAD-ICDH assay: 50 mM Tris-HC1 (pH 7.4), 200 mM.
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In vitro antibacterial activity of different adenosine analogues
including adenine and 1/3-deazaadenine derivatives substituted in the 2- ... The intact sugar moiety seemed to be not essential for antimicrobial activity ... bacterial enzymes, such as purine nucleoside phosphorylases .... compounds is very similar to that of the previously reported. NAD. +. -dependent DNA ligase inhibitors.
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Full-Text PDF - MDPI
Oct 26, 2012 ... and expedient, the azide and alkyne moieties are physiologically .... ethylpiperidine purine analogue 5 (Figure 1) was substituted into ..... inhibited an E. coli nicotinamide adenine dinucleotide malic enzyme (NAD ME) [99].
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full text - pdf 501 kB - iupac
analogues substituted with spacer molecules at various positions on the purine, phosphate and ribose moieties and suitable for attachment to insol- .... Nevertheless, nucleotides such as NAD may be readily immobilised with diazonium.
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2′-Deoxy Cyclic Adenosine 5′-Diphosphate - ACS Publications
Feb 28, 2008 ... Some 8-substituted 2′-deoxy analogues showed agonist activity at higher concentrations, among which ... metabolite of nicotinamide adenine dinucleotide (NAD. +. ). cADPR is a potent .... nicotinamide moiety even at ambient temperature. ..... that these two riboses were connected to the purine base by a.
[ Potter_JMC_2deoxycADPR_mar08_published.pdf - Read/Download File

1 synthesis of c-2 and c-6 functionalized ribofuranosylpurine
NAD as a cofactor. XMP is ... spectrum antiviral), which is active due to its C-2 vinyl moiety acting as a Michael Acceptor. ... These novel compounds were designed mechanistically as transition-state analogues similar to ...... purines, such that nucleophilic substitution reactions are the predominant reaction types on the.
[ bonsu_eric_o_200505_phd.pdf - Read/Download File

C-Nucleosides To Be Revisited - American Chemical Society
Oct 29, 2015 ... analogues. This means that their heterocyclic moiety (mostly purine or pyrimidine ) is linked to their sugar part (mostly ribose or 2-deoxyribose) .... 5′- monophosphate and then anabolized to an analogue of NAD, namely, TAD .... pyridin-2-yl and 6-substituted pyridin-3-yl C-nucleosides (27)83,84 have been ...
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sympathetic and sensory-motor neurotransmission via - Europe PMC
the vitamin nicotinamide and structural analogues of NAD and NADP were tested in the isolated ... 1994); however, in a revision of purine receptor taxonomy ... moiety witha second ribose sugar attached to the P-phos- ...... they are substituted.
[ brjpharm00168-0024.pdf - Read/Download File

In Vitro Evaluation of Nicotinamide Riboside Analogs against
May 7, 1990 ... report the effects that NAD and NR analogs have on the growth of H. ..... Purine alteration. NHD ... Compounds in which only the adenine moiety was modified ... 3'-substituted riboside that was unable to support the growth.
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Full-Text PDF - MDPI
Dec 27, 2011 ... acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by .... pyrimidine or as -triazine moiety as nucleobase appended to 1,2,3-triazole. ..... consisting of MH + 5 g/L yeast extract + hemin 15 mg/L + NAD ..... Parkanyi, C.; Yuan, H.L. Synthesis of acyclic nucleoside analogs of 6-substituted 2-aminopurines.
[ molecules-17-00179.pdf - Read/Download File

Human Aldehyde Dehydrogenase Catalytic Activity and Structural
ordered with NAD binding before aldehyde. With E1, the ... tions in the purine moiety of the coenzyme are tolerated in retaining coenzyme functioning ..... zyme analogs substituted in the adenine ring behaved similarly with all three isozymes  ...
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Bioisosterism: A Rational Approach in Drug Design
moiety in the case of 6,9-disubstituted purines (Table. 6) has been shown to ..... study demonstrated that the bromo-, hydroxyl-, and thio-substituted analogues ..... NAD-dependent inosine monophosphate dehydroge- nase (IMPD). Inhibition of ...
[ 1996chemrev96-3147-76_bioisosterism.pdf - Read/Download File

Standard PDF (984.5 KB) - Wiley Online Library
The analogs were substituted at C-6 or C-8 with a 4-(2,2,6,6-tetramethyl- piperidinyl-l ... is at least 1.5-2.0 nm apart from the adenine moiety of the coenzyme. Although a direct ... (NADH) and SL8-NAD+ (NADH), nicotinamide - purine dinucleotides substituted at ... fication and synthesis of NAD' analogs were performed as.
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PDF (1456 KB) - Annual Reviews
of the conformation of the protein moiety are being examined by optical ..... and an NAD heavy atom analogue as isomorphous heavy atom derivatives by these authors ... in showing purine nucleotide effects, but the mammalian, avian, and frog .... cludes both their experiments with isotope substitution for various hydrogen.
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