MT2MMP Expression During Early Avian Morphogenesis
Nov 15, 2012 ... ABSTRACT. Membrane-type 2 matrix metalloproteinase (MT2-MMP; also called. MMP15) is ..... MMP-2 expression during early avian cardiac and neural crest ... crest cell migration and its role in proMMP-2 activation. Dev Dyn.
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MMP-2 plays an essential role in producing epithelial-mesenchymal
MMP-2 is expressed as neural crest cells detach from the neural ... motility during the EMT and during later morphogenesis. ... MMP-2 expression in the dorsal neural tube using antisense morpholino oligos perturbs the EMT, but also ... gration of cardiac cushion cells .... ESSENTIAL ROLE OF MMP-2 IN AVIAN EMBRYO 43 ...
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Expression of tissue inhibitor of metalloproteinases (TIMPs) during
TIMP-2 expression during early cardiac morphogenesis and septation. .... MMP-2 expression during early avian cardiac and neural crest morphogenesis. Anat.
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Extracellular metalloproteinases in neural crest development and
Sep 25, 2013 ... The neural crest (NC) is a population of migratory stem/progenitor cells that is found in early vertebrate embryos. NC cells are induced during gastrulation, and later migrate to ... in NC development and related tissue morphogenesis, with a special ..... that MMP-2 expression and/or function may be restricted.
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Full Text - The International Journal of Developmental Biology
Feb 2, 2009 ... MMP-3 and MMP-8 inhibitors had no effect on neural crest migration. Expression studies showed ...... Mmp-2 expression during early avian cardiac and neural crest .... Collective cell migration in morphogenesis and cancer.
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Circulating Matrix Metalloproteinase-2 and -9 Enzyme Activities in
Jun 12, 2013 ... We studied the changes of circulating MMP-2 and MMP-9 activities in the patients ... and 50%, respectively, during a mean follow-up of 12 months . ..... early avian cardiac and neural crest morphogenesis. Anat Rec ... regulation of matrix metalloproteinase gene expression: can MMPs be good for you?
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Epithelial to mesenchymal transition: New and old insights from the
The neural crest (NC) is a transient embryonic cell population characterized by its .... pattern in prospective NC cells prior to and during early migration  and is a well-known .... Indeed, specific morpholino knockdown of MMP2 expression in the dorsal neural ..... during early avian cardiac and neural crest morphogenesis.
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Diminished Matrix Metalloproteinase 2 (MMP-2) in
During early vertebrate embryogenesis, neuroepithelial cells from the cranial neural folds (i.e., the cranial neural crest) undergo an epithelial-to-mesenchymal ...
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Invasion by Matrix Metalloproteinase-Expressing Cells Is - Karger
Feb 16, 2010 ... 72-kDa MMP-2 and 2 kinds of MT-MMPs (MT1-MMP and MT3-MMP) ... 2002; Linask et al., 2005] and neural crest [Cai et al., 2000;. Cai and ...
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Collective cell migration of the cephalic neural crest: The art of
Key words: neural crest cells; collective cell migration; chemotaxis ...... MMP-2 expression during early avian cardiac and neural crest morphogenesis. Anat.
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Early Events in Valvulogenesis: A Signaling Perspective - Vanderbilt
death during childhood (Galloway et al., 1999). Although ... diac morphogenesis consists of the ... the early specification and assembly of components of the cardiovascular ... mesenchyme, and neural crest cells ... Figure 2. Stylized depiction of AV cushion remodeling into mature valves. ... expression (ten Dijke et al., 1994a).
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Matrix Metalloproteinase-Induced Epithelial - Springer
May 5, 2010 ... morphogenesis, but they are also upregulated in breast cancer, where they stimulate ... (denatured collagen)-cleaving MMPs (MMP-2 and -9) were ...... MMP- 2 expression during early avian cardiac and neural crest morpho-.
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Expression and localization of matrix metalloproteinases (MMP-2,-7
Sep 22, 2015 ... ... of the MMP system in avian oviduct development, mRNA and protein expression, ... to be essential for tissue growth and morphogenesis. Numerous ...... metalloproteinase-2 (TIMP-2) expression during cardiac neural crest cell migration .... teinases MMP2 and MMP9 are produced in early stages of kidney.
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Download Article PDF
laborious. This review will discuss MMP biology, current methods for detection of MMPs from patient samples, and poten- ... 2. 4. 1. Cleaves collagen and gelatins. MMP-3. Stromelysin 1. P08254 ..... molecules and protein expression profiles of patient ..... sion during early avian cardiac and neural crest morphogenesis. Anat.
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Cadherin-6B is proteolytically processed during epithelial-to
Jan 1, 2014 ... Department of Animal and Avian Sciences, University of Maryland, ... with γ- secretase, during cranial neural crest cell EMT. ... hamster ovary cells were chosen for stable Cad6B expression, as ..... ADAMs, MMP2, or the control pCIG construct (*p < 0.05, n = 2). ...... during avian epithelial morphogenesis.
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The Role of Cardiac Neural Crest Cells in Zebrafish Heart
neural crest cells (CNCCs), which also contribute to later stages of cardiac development are well studied in chick .... Figure 3-2. bmp4 is increased in neural crest ablated embryos … ... MT2-MMP expression during early avian morphogenesis.
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Apoptosis During Cardiovascular Development - Gladstone Institutes
Abstract—Morphogenesis and developmental remodeling of cardiovascular .... Early studies of cell death in the cardiovascular system used ... lence declined during the first 2 weeks of life and was 4- to ... indicated that neural crest cells, in addition to incorporating ..... fragment of MMP-2 (hemopexin-like domain, PEX) can.
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Valvulogenesis: the moving target - Butcher Lab
Jun 14, 2007 ... living with heart defects acquired during embryonic development. Many of these ... The early embryonic heart is a single ..... that no residual neural crest cells persist in the outflow tract (de .... TGF-b3 induces expression of MMP-2 and MT- MMP, which .... during avian cushion morphogenesis, as well as.
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Leptin affects endocardial cushion formation by modulating EMT
Aug 29, 2007 ... tration of recombinant leptin is required during conception, ... creased matrix metalloprotease 2 (MMP2), suggesting a leptin signaling ... abate; however, expression in the endocardium and mesenchymal ... 1 E ), and early remodeling ( Fig. ..... neural crest formation, cardiac morphogenesis, and sclerotome.
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Notch Signaling in Cardiac Development - Circulation Research
May 23, 2008 ... Morphogenesis ... a role for the Notch pathway during cardiac neural crest cell development has been identified, .... early stages of mesoderm formation in the primitive streak, at ... cardium, BMP2-Tbx2 signaling represses Hey1/2 expression .... proteinase 2 (MMP2) expression.61 MMP2, in addition to.
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