Kinetic resolution of 1-phenylethanol integrated with separation of
Oct 9, 2008 ... integrated with separation of substrates and products .... Stoichiometric scheme of kinetic resolution of rac-1-phenylethanol catalysed by CALB.
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Full-Text PDF - MDPI.com
Sep 15, 2015 ... Keywords: enzyme catalysis; ionic liquids; bioseparation; whole cell biocatalysis; ... substrates have been covalently attached to an ionic liquid prior to ...... catalysed kinetic resolution of 1-phenylethanol with improved enantioselectivity. .... development of an integrated membrane process with ionic liquids ...
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Organocatalytic Acylation for the Kinetic Resolution of - DiVA
Nov 28, 2014 ... ... acetylation of. (R)-1-phenylethanol catalyzed by a planar-chiral DMAP catalyst. ... kinetic resolution of 1,2-azidoalcohols using a planar-chiral DMAP derivative ... thesis of racemic substrates; designed and carried out all the ki- ..... New recent advances in asymmetric synthesis and chiral separation have.
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Download as PDF - InTech
Feb 21, 2011 ... of substrates in aqueous medium may require the enzymatic reactions to be carried ... integrated reaction and separation processes. ..... the kinetic resolution of rac-1-phenylethanol in both IL/hexane and SC CO2/IL biphasic.
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PDF Full-text - MDPI
Jun 13, 2016 ... because they resemble the surface of their natural substrates , but .... supports —similarly to the usual epoxy carriers—can be stored for a long time enabling real separation ... Kinetic resolution of 1-phenylethanol (rac-1) catalyzed by CaLB on ..... enantiomers of 1 and 2 using precise integration methods.
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Chapter 4 – A Model for Selectivity in the Oxidative Kinetic Resolution ..... kinetic resolution substrate 1-phenylethanol (21) is α-(trifluoromethyl)benzyl alcohol ...
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Mechanistic Aspects on Cyclopentadienylruthenium Complexes in
May 30, 2013 ... and (ii) the method requires separation of starting material and product. ... an enzyme-catalyzed kinetic resolution is integrated with an in situ racemization of the remaining substrate ... (Figure 1) have all been employed as racemization catalysts ...... phenylethanol ((R)- and (S)-6) is not the same because of ...
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Green Chemistry themed issue - RSC Publishing - Royal Society of
Jan 10, 2012 ... Expanding the organic toolbox: a guide to integrating biocatalysis .... tedious separation steps of undesired isomers. ... natural substrate scope, which typically translates into a fairly ... racemic form for enzymatic kinetic resolution using a lipase ..... kinetic resolution of racemic 1-phenylethanol, an important.
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Synthesis of a Racemic Ester and Its Lipase-Catalyzed Kinetic
For an integrated biochemistry and chemistry ... 1-Phenylethanol, 1, was chosen as substrate for the re- ... sists of two separate steps: the synthesis of a racemic ester and the kinetic resolution thereof, catalyzed by an enzyme. In the first step, ...
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Zhao & Ding/ACS Catal. 2013, 2, 928-944 - FONCER en science en
Mar 19, 2013 ... examples in fast catalyst screening, integrated inline/onlineanalysis, microflow photocatalysis, ... addition, biocatalysis, including enzyme-catalyzed kinetic resolution and transformation, ... both academia and industry.1,2 Asymmetric catalysis3,4 is, in ... and separation when performed in a continuous-flow.
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Ionic liquids in biotechnology: applications and - Springer
Oct 21, 2008 ... Furthermore, integration of reaction and separa- tion has a high potential in ... IL can provide gains for activity, stability and separation as properties can be ... For the kinetic resolution of (R,S)-1-phenylethanol via transesterification ... dissolved substrates to less than 5% loss of activity within. 4 h. Increased ...
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E. coli/ADH-A: An all-inclusive catalyst for the selective biooxidation
addition of these substrates to the E. coli/ADH-A cells in buffer ... Scheme 1. a) ADH-catalysed oxidative kinetic resolution; and b) ... Thus, racemic 1- phenylethanol (1a, 40 mM) was added to a ... To confirm the presence of an integrated NAD+ regeneration ..... separated by column chromatography (Et2O) as previously.
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G. Kinetic resolution of 1-phenylethanol integrated with separation of substrates and products by a supported ionic liquid membrane. J Chem Technol Biotechnol ...
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New Generations of Ionic Liquids Applied to Enzymatic - InTech
zyme due to: (1) the interaction with the substrates or products, as organic solvents ; (2) interaction ... ously recommended IL, combined with product separation using a membrane bioreactor. (the so-called process integration). ...... lipase catalysed kinetic resolution of 1-phenylethanol with improved enantioselectiv‐ ity.
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Asymmetric reactions in continuous flow - Beilstein-Institut
Apr 29, 2009 ... nology has excellent potential for the integration of a high level ... and related substrates (Scheme 2) [13,14]. ... complete separation of these components from reaction .... Scheme 10: Continuous-flow hydrolytic dynamic kinetic resolution of .... racemic 1-phenylethanol 54 was performed continuously in.
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I Methodology - Wiley-VCH
In an enzymatic resolution of a racemic substrate, the E value can be .... Finally, as an 'old' example of kinetic resolution of racemic mixtures, mention must be made .... This simplifies catalyst–product separation and enzyme reutilization. ... catalyzed transesterification of racemic 1-phenylethanol (10) using vinyl butyrate as.
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Synthesis of enantiopure chloroalcohols by enzymatic kinetic
Table 1 HheC-catalyzed kinetic resolutions of substrates 1–7 on analyt- ical scalea ... equations by numerical integration to the obtained data points,15 the E- value .... for the related compound 2-chloro-1-phenyl-ethanol, made us reconsider. ... procedure.10 Spectroscopic data and chromatographic separation conditions ...
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A tandem enzyme reaction to produce optically active halohydrins
merically pure halohydrins and epoxides by kinetic resolution. ... dichloro-1- propanol (E>100) and (S)-2-chloro-1-phenylethanol (E=73) were ... Halohydrins used as substrates by the halohydrin dehalogenase from ... When, in a separate experiment, enantiomerically pure (R)-styrene oxide or (R)-m-chlorostyrene oxide.
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PDF (1988 KB) - Annual Reviews
Mar 1, 2011 ... small-scale integrated circuits (4). ... yield reaction is not enough; separation of the desired product from the .... the challenges of enzymatic reactions of hydrophobic substrates in aque- ... (35) reported the kinetic resolution of rac-1- phenylethyl ... (R)-1-phenylethanol at room temperature in 30 vol% organic ...
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Ionic liquids and continuous flow processes - Universidad de Murcia
Mar 18, 2015 ... together in order to develop new greener alternative solvents.1. The main aim is to ..... catalyzed kinetic resolution of racemic 2-(1H-imidazol-yl)- cycloalkanols.27 The ... in ILs, product separation and recycling of the catalyst-IL phase.32 .... 7 Continuous flow biocatalytic process in ILs integrating synthesis.
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