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Get PDF (85K) - Wiley Online Library
Sep 17, 2008 ... invasive surgery with Halsted's radical mastectomy, the initial National Surgical. Adjuvant .... would eventually be possible to identify high-risk ... have no effect on patient survival, it would provide ... came during World War II, when nitrogen mustard ... only 3 treatments at and immediately after surgery.
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Extravasation guidelines 2007 - the European Oncology Nursing
given every day around the world, keeping adverse events and ... the clinical setting – from prevention and recognition to possible treatment with ... The nurses who routinely provide cancer therapies intravenously (either .... The initial symptoms of extravasation occur immediately after the blood vessel ..... (Nitrogen mustard).
[ EONSClinicalGuidelinesSection6-en.pdf - Read/Download File

Glucocorticoids in clinical oncology - Cleveland Clinic
of side effects depend on the total dose and the duration of therapy, but optimal dosages for these drugs ... Immediately ... rapidly absorbed after oral administration. .... IV).5°'51 In the original program, prednisone was given ... and endocrine therapy are superior to mastectomy ... MOPP Nitrogen mustard, vincrisrine, 50,51.
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management of breast cancers during pregnancy - cngof
as closely as possible to standard protocols including surgery without ... therapies is not recommended during pregnancy given the limited data ... effect on the risk of breast cancer: it increases transiently after childbirth but then falls after 15 ..... Moreover, some agents such as nitrogen mustards are bound to tissues, with ...
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Leukemia in Breast Cancer Patients Following Adjuvant
risk was 0.06% after 10 years in those free of metas- .... and total mastectomy plus radiation of the chest wall, axilla, ... that variation in local-regional treatment failed to affect out- ... regimen L-phenylalanine mustard (L-PAM) plus 5- fluorouracil .... 5-FU, methotrexate, and Coryne bacterium parvum given intravenously; L-.
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where there is no oncologist - PROFOH
(where possible/advisable) or refer them for advanced treatment. The last .... The important toxic effect of therapeutic doses of virtually all ... Azospermia: cyclophosphamide, nitrogen mustard, thiotepa, methotrexate ..... Mastectomy or radiation ... Fluorouracil 425 mg/m2 IV push days 1-5 (immediately after leucovorin).
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Landmarks in Cancer Research - American Association for Cancer
are events or discoveries after 1907 that have had a profound effect on advancing our knowledge of the .... Intravenous nitrogen mustard was shown to slow the ...
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CMF revisited in the 21st century
Jun 29, 2011 ... One possible justification for supporting ... investigate whether, after observing the classical CMF being overtaken ... which all three drugs were given i.v. on days 1 and 8 with those ... other drugs, as leukeran, nitrogen mustard, and vincristine, .... endocrine effects of chemotherapy in premenopausal patients.
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in the diagnosis of jaundice - Gut
provided consideration is given to the other factors which affect the level of activity .... immediately after operation, the lowest value being ... after mastectomy . ..... Nitrogen mustard therapy for metastatic carcinoma ... developed jaundice following intravenous nitrogen ..... Another possible explanation is that the sheer bulk.
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An Initial Report on Effect in Advanced Breast Cancer
sequelae after such irradiation, and delibera- tions upon ... Other side-effects of less readily identifiable character may be possible. ... radical mastectomy 6 years before the ultrasound ... No specific therapy was given for 6 .... intravenously at the rate of 0.25 ml. per kg. ..... in the nitrogen mustard administration in the lung.
[ Hickey-ArchSurg-620-1961.pdf - Read/Download File

PDF (300 KB) - Annual Reviews
achieve this effect without pulmonary irradiation, with its known compromise of .... to be more effective than a single oral drug, L-phenylalanine mustard ... given for two years, with median follow-up of nine months after initiation of the study ... monthly cycles of CMF versus no treatment following mastectomy, there were 5.3 %.
[ annurev.me.28.020177.002355 - Read/Download File

Some Biological Effects of Vincaleukoblastine, an Alkaloid in Vinca
effects were noted at the sites of injection, on the blood, and on the nervous system. ... be possible. The 22 patients ... c) Blood pressure immediately following treat ... and after treatment. ... study was 0.15 mg/kg, given intravenously for ..... Nitrogen mustard, nitrogen mustard com ... This patient had left radical mastectomy.
[ 1032.full.pdf - Read/Download File

Adverse mucocutaneous reactions related to chemothera - SciELO
Side effects range from the common to the rare .... ally disappears some months or years after discontin- .... (topical nitrogen mustard) ..... Grade IV Anaphylaxis ... occur if appropriate treatment is not given, leading to ... short as possible. ... radiation, the ipsilateral limb to a mastectomy, in vena ... infusion immediately.
[ en_v85n05a02.pdf - Read/Download File

Download PDF - Plos
Jul 16, 2014 ... The dogs were then given cyclophosphamide, one of the standard chemotherapeutic agents used for the ... mammary cancer develop a new tumour after the surgical removal ... amide mustard, but the cells are only killed when they try to divide. ... mammary tumour, four animals (IV, IX, XII, and XIII) had two.
[ Michalowski et al dog trial PLOS ONE.pdf - Read/Download File

A SCIENTIFIC ESSAY* REGARDING A 25 YEAR - Waisbren Clinic
Finally, they are made to understand that all treatments are to be given in ... successes, and 10 patients in whom the treatment was considered as a possible salutatory result ... shrank and she returned to full employment after a year of immunotherapy ... The effect of immunotherapy on surrogate markers of cancer also.
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SCAI Expert Consensus Statement: Evaluation, Management, and
Jan 9, 2016 ... In addition to the known effects on cardiac function, ... abnormal vasoreactivity immediately after the initiation of therapy ... Often given in combination with cisplatin, bleomy- .... Estrogen/nitrogen mustard ..... guidance all contribute to the best possible ... patients who have undergone bilateral mastectomy are.
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BIOETHICAL ISSUES IN CANCER BIOGRAPHY Elena-Luminiţa
knowledge is possible only by experiment, ideas validated by studies, ... given to malnourished patients had a positive ... recurrent breast cancer after mastectomy. ... radiation therapy has localized effect, but ... administer intravenously multiple doses ..... Nitrogen Mustard Therapy: Use of Methyl-Bis(Beta-Chlorethyl) amine.
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Infiltration and Extravasation - GAVeCeLT
become evident only days or weeks after exposure.7,10. Variables ... The impact appears to depend ... tion of IV fluids immediately; (2) disconnect the IV tub- ing from ... extravasation, whenever possible.29-32 .... tive antidote to mechlorethamine (nitrogen mustard).40 .... patients who were given hyperbaric treatment follow-.
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