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Interleukin-6, A Grown-Up Cytokine in EAE - Austin Publishing Group
Jun 16, 2016 ... number of studies: systemic IL-6 KO mice are resistant to EAE [17-. 21], and ... and functions, interferon b2 [3,4], hybridoma growth factor [5], .... autoimmune encephalomyelitis: A study in gene-targeted mice. European.
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Astrocytic IL-6 Influences the Clinical Symptoms of EAE in Mice - MDPI
May 17, 2016 ... Mendel, I.; Katz, A.; Kozak, N.; Ben-Nun, A.; Revel, M. Interleukin-6 functions in autoimmune encephalomyelitis: A study in gene-targeted mice.
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IL-6–Dependent Autoimmune Disease - The Journal of Immunology
Interleukin-6 is a potent proinflammatory mediator with key roles in ..... Interleukin -6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice.
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The pro- and anti-inflammatory properties of the cytokine interleukin-6
In classic signaling, interleukin-6 stimulates target cells via a membrane ... Apparently, IL-6 via classic signaling has regenerative and anti-inflammatory functions ..... In a recent study, mice with a conditional targeted IL-6R gene were analyzed ..... IL-6−/− mice are protected from experimental autoimmune encephalomyelitis.
[ 1-s2.0-S0167488911000425-main.pdf?_tid=99e1ffbc-3c00-11e4-9fb5-00000aab0f26&acdnat=1410693580_b03a81daf1389bebe0e85246de9bb96a - Read/Download File

Interleukin‐6 is a direct mediator of T cell migration
To clarify whether IL-6 functions as a migration factor, we ...... Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice. Eur.
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Leukemia Inhibitory Factor, Interleukin 6, and Other Cytokines Using
and in some cases, overlapping functions. One of the shared receptor ... IL-6, LIF, and Related Cytokines in Inflammation and Injury. There has been a ..... autoimmune encephalomyelitis: a study in gene-targeted mice. Eur J Immunol 1998 ...
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Download as Adobe PDF - Edinburgh Research Explorer - The
'Cutting Edge: IL-6-Dependent Autoimmune Disease: Dendritic Cells as a Sufficient, but Transient, ..... Mendel I, Katz A, Kozak N, Ben-Nun A, Revel M. Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene- targeted mice.
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Prof. Michel REVEL PUBLICATIONS Selected full research articles
Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene- targeted mice. I. Mendel,. A. Katz, N. Kozak, A. Ben-Nun and M. Revel. Eur. J. Immunol.
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Astrocyte response to IFN-γ limits IL-6-mediated microglia - Springer
autoimmune encephalomyelitis (EAE) correlated with elevated expression of interleukin (IL)-6, a cytokine with pleiotropic functions and therapeutic target for non-central nervous system (CNS) ..... were normalized to the housekeeping gene GAPDH and ...... of interleukin-6 expression in the brain: studies in transgenic mice.
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Kinetics of IL-6 Production Defines T Effector Cell - Plos
Oct 14, 2013 ... IL-6 also changed the kinetics of IL-6 production and induced Treg unresponsiveness. This modulation was ... Foxp3+ Treg conduct their suppressive function via direct cell contact [1]. .... human Interleukin-6 (R&D systems). ...... functions in autoimmune encephalomyelitis: a study in gene- targeted mice. Eur.
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PDF(393K) - Wiley Online Library
barrier and attenuates experimental autoimmune encephalomyelitis. Daniel Offen,* Yossi ... and interleukin-6,5. The concept now emerging is that ROS specifically target ... quently regulating gene expression, cellular proliferation, inflammation, and ...... Interleukin-6 functions in autoimmune encephalomyelitis: a study.
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B cell depletion therapy ameliorates autoimmune disease through
Aug 9, 2011 ... from mice with experimental autoimmune encephalomyelitis (EAE) secreted elevated levels of IL-6 compared with B cells .... functions of B cells in RR-MS is IL-6, which is essential for ...... secrete high levels of interleukin-6. .... functions in autoimmune encephalomyelitis: a study in gene-targeted mice. Eur.
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Adjuvant Immunotherapy Is Dependent on Inducible Nitric Oxide
Jun 4, 2001 ... tempts to induce autoimmune disease, while animals immunized with ... of the MOG-specific IgG1 response, a decrease in interleukin 6 ... CFA Pretreatment and Experimental Allergic Encephalomyelitis In- duction. ..... Interleukin-6 functions in autoimmune encephalomy- elitis: a study in gene-targeted mice.
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accepted manuscript - Hal
Dec 16, 2011 ... autoimmune encephalomyelitis was the induction of EAE in IFNγ and IFNγ ... potential therapeutic target, was not the determining factor for CD4 T cell encephalitogenicity. Several studies found that IL-6 and TGFβ were sufficient to ... encephalitogenic T cells, the IL-23 receptor and osteopontin genes have ...
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IL-6 and Inflammatory Diseases - Springer
Abstract Interleukin-6 (IL-6) is a multifunctional cytokine that plays key roles not ... excellent target for clinical treatment, as the anti-IL-6 receptor antibody has been ..... Genome-wide association studies have found a genetic link between the .... arthritis and experimental autoimmune encephalomyelitis (EAE), a disease that.
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Cytokine production profiles in chronic relapsing–remitting
experimental autoimmune encephalomyelitis: IFN-γ and TNF-α are important participants ... Interleukin-6 (IL-6). Multiple sclerosis ... In the present study, we induced CREAE in NOD mice by immuni- zation with .... evaluate alterations in target gene expression level in CNS tissue. 2.6. .... While its function is unknown, a num-.
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Linkage of IL-6 with Neutrophil Chemoattractant Expression in Virus
2002;43:737–743). Interleukin-6 (IL-6) is a cytokine that is rapidly produced at ... of IL-6, studies have been conducted in gene-disrupted mice. It ... resistant to experimental autoimmune encephalomyelitis.4,5 ... However, IL-6 can also function as an anti-inflammatory ..... Thus, IL-6 represents a potential therapeutic target for.
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FLT-3 expression and function on microglia in multiple sclerosis
May 31, 2010 ... autoimmune encephalomyelitis (EAE), an animal model for MS, are ... Evidence from in vitro and in vivo studies suggests an important role .... 6. These findings suggest that FLT-3 is a relevant target within MS ..... metalloproteinase-9) and interleukin-6 by activated rat microglia in culture. .... Gene-microarray.
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Differential expression of suppressors of cytokine signaling-1 and-3
(EAE), whereas C57BL/6 (B6) mice display a more chronic course without complete remissions. .... housekeeping gene GAPDH, as well as the target genes , were ..... Interleukin-6 functions in autoimmune encephalomyelitis: a study.
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Role of Gamma Interferon in the Pathogenesis of Severe
In the absence of interleukin-4 (IL-4), infection with Schistosoma mansoni leads to a severe .... vitro, rat anti-IFN- MAb XMG.6 was added to culture wells at 10 g/ ml. ..... functions in autoimmune encephalomyelitis: a study in gene-targeted mice .
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