Structural domains of interleukin-2 receptor critical for signal - NCBI
with Boxl-Box2 for IL-2-induced proliferation were identified. ... interferon receptors [29-31]. The Jak-Tyk family of ... Jak-like kinase. ... YT cells, a human natural killer cell line, were ..... 2R/3: (1) the Boxl-Box2 domain of IL-2R,l is not sufficient for.
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Interleukin 2 and interleukin 15 differentially predispose natural killer
tumour target cells, induce apoptosis of IL-2-primed NK cells; (ii) ... not yet activated, generates lymphokine-activated killer cells that are efficient ... IL-2 with intermediate affinity, and is sufficient for NK cell ... cell line CV1/EBNA (Grabstein et al, 1994), similar to IL-2, is ..... 12 which induces resting NK cells to interferon gamma.
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Early Production of γ-Interferon in Clinical Malaria: Role of
IFN, interferon; IL, interleukin; NK, natural killer; TNF ... early g-IFN responses, either for malaria- ... 2. Adachi K, Tsutsui H, Kashiwamura SI, et al. Plasmodium berghei infection in mice in- duces liver injury by an IL-12– and Toll-like ... mune response to malaria: rapid induction of .... these cytokines alone were not sufficient.
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Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals
Jun 15, 2010 ... was insufficient to induce robust expansion. Proliferation of ... We recently identified a subset of natural killer (NK)-like cells in human tonsils ..... The IL-2– induced deviation of NK-22 cells toward IFN-γ pro- duction mirrors the ..... (2007) Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
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Natural killer cells: In health and disease - ScienceDirect.com
Natural killer (NK) cells constitute our bodies' frontline defense system, guarding against ... such as interferon, which stimulate a more efficient killing response by the T cells. ... The transition from fetal NK-cell development to a more adult-like NK-cell state ..... Natural killer and interleukin-2 induced cytotoxicity in asthmatics.
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Interleukin-22-Producing Natural Killer Cells and Lymphoid Tissue
Jul 16, 2009 ... Initially, human NK cells were classified into two subsets, on the basis of the ... Whereas CD56bright NK cells preferentially secrete IFN-γ, ... Human and Mouse IL-22 Producing NK and LTi-like Cells in the Gut and ..... 2003), does not induce IL-22, at least in human mucosal NK cells (Cella et al., 2009).
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Natural killer cells take two tolls to destruct bile ducts
interferons (IFNs), interleukin-2 (IL-2), IL-18, IL-12, ... NK, natural killer; PBC, primary biliary cirrhosis; TLR, toll-like receptor; ... against autologous liver cells because it is often not feasi- ... This suggests that LPS alone is sufficient to stimulate.
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Lymphokine-activated Killer Activity in Long - Cancer Research
Peripheral blood lymphocytes cultured in recombinant interleukin 2 during 3 to 5 ... culture with OKT3 + IL2 induced increases in the numbers not only of CD3* ...
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Cells to NK Cell Stimulatory Factor (NKSF) - The Journal of
Like interleukin 2 (I1-2), NKSF augmented the lysis of NK- sensitive ... (1, 2). Sufficient concentrations of Ib2 dra- ... tivities in vitro, including the induction of IFN-3, secretion .... CD56 mAb used does not affect NK cell proliferation or cytolytic.
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identification and purification of natural killer cell stimulatory factor
of NK cells because in the absence of B cell lines neither high doses of IL-2 alone ..... has no IFN--y-inducing, NK cell-augmenting, or comitogenic activity when tested on PBL (24). ... tration is sufficient to induce a modest increase in NK cell-mediated cytotoxicity. (25) . ..... I. Production of both interleukin 1-like activity and an.
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cyclosporin a inhibition of interleukin 2 gene expression, but not
NK cells. Thus, IFN-induced NK cell expansion appears to involve an as yet unidentified ... abrogated poly(I :C)-induced IL-2 gene expression in athymic mice , it did not block. NK cell ...... The p55 chain is not sufficient to mediate a cellular.
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IL-12 Induction of CD25 To Form High-Affinity IL-2 Recept
NK cell expression and use of the IL-2Ra–chain (CD25), ... not the NK activating receptor Ly49H, are required ... components for multiple cytokines and sufficient to stimulate .... enriched populations were similar. To evaluate CD25 induction on . NK1. ... fected B6 mice were stimulated in 96-well plates with type I IFN (rmIFN-a .
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Synergy among receptors on resting NK cells for the - Blood Journal
(TNF- ) and interferon. (IFN- ), and to ... receptor is necessary or sufficient to activate NK cells and to what extent ... been used to block lysis of tumor cells by interleukin 2 (IL-2)– activated ..... Freshly isolated, resting NK cells did not induce lysis of P815 cells either ..... not cytotox- icity by the killer cell Ig-like receptor KIR2DL4.
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Phase I Evaluation of Recombinant Interleukin-2 in Patients With
were treated with recombinant human interleukin-2. (IL-2) administered by ... cell- mediated cytotoxicity against natural killer (NK)- ... IL-2. This effect was independent of fever and was not abrogat- .... Interferon (IFN) levels were determined by radioimmunoassay using a kit .... 2 were sufficient to induce antibody formation in.
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A Novel Costimulatory Factor for Gamma Interferon Induction Found
the ability to induce IFN- , this protein augmented T-cell proliferation and NK activity in the spleen cells. Thus ... vious studies, an interleukin-12 (IL-12)-like, 75 -kDa IFN-- inducing ... treated mice 2 h after the challenge with LPS on the same days that mice were ..... the factor was not sufficient for IFN- induction and further.
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Increased natural killer cell cytotoxicity and NKp30 expression
IL-2–induced cytolytic activity and higher levels of the natural cytotoxicity receptor NKp30- activating ... interferon-c; IL-2, interleukin-2; LAK, lymphokine-activated killing; NCR, ... dominantly inhibitory killer immunoglobulin-like ..... expression on NK cells and LAK activity only and not with the expression of other NK receptors.
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Enhancement of Human Natural Killer Cells by interferon Requires
IF-induced enhancement was unaffected by incubation of effector cells with ... (2- 2). The subset of lymphocytes mediating NK activity in man has not been com- ... leukocyte interferon: IL-2, interleukin-2: MC, mitomycin C: NK. natural killer; PBMC, ..... a brief interaction of cells and IF seems sufficient to initiate both induction of.
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Concomitant increase of LMP1 and CD25 (IL-2-receptor [alpha
Sep 29, 2006 ... nasal NK/T-cell lymphoma; IFN-g; IL-10; CD25 (IL-2R a). Extranodal ... cause it can induce transformation of rodent fibroblast cell lines ... EBNA-2 is not expressed, thus the regulation of LMP1 expression ... IFN, interferon; IL, interleukin; LCL, lymphoblastoid cell line; LMP, ..... vacciniforme-like eruptions.
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Psychological Stress-Induced Modulation of Interleukin 2 Receptor
*We explored the expression of the interleukin 2 receptor (IL-. 2R) and the synthesis ..... tion provided by the antibody was similar to that observed in CTLL. 20 cultures .... 2-induced up regulation of IL-2R expression is not sufficient to overcome .... presses interferon production and natural killer cell activity in humane. Behav.
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Role of chemokines in the biology of natural killer cells - CiteSeerX
Moreover, NK cells secrete cytokines, such as interferon-γ. (IFN-γ) ... γ common chains of the interleukin (IL)-2 and IL-15 receptors ... like CD4 T cells, predominantly regulate other cells through .... CCL21 do not stimulate significant chemotaxis of resting pe- ..... IFN-γ in vivo is necessary but not sufficient for the antitumor.
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