Induced Nanoelectrospray Ionization for MatrixTolerant and
Sep 5, 2011 ... Induced Nanoelectrospray Ionization for Matrix-Tolerant and High-. Throughput Mass Spectrometry**. Guangming Huang, Guangtao Li, and R.
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Online Inductive Electrospray Ionization Mass - ACS Publications
Apr 12, 2016 ... was also monitored by traditional off-line nanoelectrospray ionization .... (MS/MS) using collision-induced dissociation (CID). An isolation ..... Ionization for Matrix- Tolerant and High-Throughput Mass Spectrom- etry. Angew.
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Characterization of a Fully Automated Nanoelectrospray - NCBI
mated, high throughput analyses with no carryover.The high ... Both matrix- assisted laser desorption/ionization time- of-flight mass .... were as follows: precursor mass tolerance. 2.0, ..... acid and organic solvent induce the unfolding process.
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Matrix effects: Hurdle for development and validation of bioanalytical
Jun 30, 2016 ... pressure ionization tandem mass spectrometry (LC-API-MS/MS). ... by Liquid chromatography, allows high-throughput confirmation and detection of trace materials, even in the ... matrix components that might induce ion -enhancement or ion- ...... LC columns are more tolerant than conventional ESI toward.
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The Identification of Protein-Protein Interactions of the Nuclear Pore
tained by collision-induced dissociation and tandem mass spectrometry is required ... ing matrix-assisted laser desorption ionization-time-of- ... successful high throughput protein analysis are discussed. Molecular ..... tolerance of 50 ppm. Every peak ..... acrylamide gels by nano-electrospray mass spectrometry. Nature 379,.
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Thermo Scientific LTQ Orbitrap An Overview of the Scientific Literature
with electrospray and nanoelectrospray ionization techniques thus ensuring a high degree of automation and throughput. The employment of reversed-phase ...
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Mass spectrometry in nucleic acid - Scripps Center for Metabolomics
Example data obtained from the high throughput MALDl-TOF-MS analysis ... Electrospray ionization (negative ion) mass spectrum of an oligonucleotide. ... In a set of simple experiments using an ESI collision-induced dissociation (CID) ... data were more challenging to interpret due to the background matrix interference in.
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Mass spectrometry and proteomics Steven P Gygi* and Ruedi - MIT
collision-induced dissociation. ESI electrospray ionization. FT-ICR ... MALDI matrix-assisted laser desorption ionization ... high-throughput applications and the possibility to archive samples on the ..... Mann M, Wilm M: Error-tolerant identification of peptides in sequence ... nanoelectrospray mass spectrometry. Anal Chem ...
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Full-Text PDF - MDPI.com
Jul 23, 2015 ... high-throughput performance) make this tool suitable to answer and to solve biological ..... Capillary electrophoresis and laser-induced fluorescence (CE-LIF) provide scientists with .... contrast, MALDI has a greater tolerance to salts, but matrix ions of ..... nanoelectrospray ionization mass spectrometry. Anal.
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An Introduction To Mass Spectrometry Ionization - Journal of
and matrix-assisted laser desorption/ionization. (MALDI), mass ... Ions are generated by inducing either the loss or gain of a charge .... to LC's low sample concentrations and relatively high flow rates. ..... Mann, has been called nanoelectrospray, nanospray, and ... Consequently, NanoESI is more tolerant of salts and other.
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Large-Scale Phosphorylation Analysis of r-Factor-Arrested
to induce a-mating type yeast to differentiate along a mating .... ions. Singly charged ions were excluded from MS/MS analysis. ... parameters: full-trypsin specificity, a mass tolerance of 1.1 Da, ..... for matrix-assisted laser desorption/ ionization, nanoelectrospray, ... probability-based approach for high-throughput protein phos-.
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Fast Quantitative Detection of Cocaine in Beverages Using
Extractive electrospray ionization (EESI) has been applied for direct .... thus providing a useful method for high throughput analysis of drinks. ... high sensitivity, good tolerance of matrices, readiness for miniaturization and .... Collision-Induced Dissociation Mass Spectra of Cocaine, and Its Metabolites and Pyrolysis Products.
[ 1-s2.0-S1044030509008538-main.pdf?_tid=892cff84-3f3c-11e4-93b3-00000aab0f6c&acdnat=1411049176_1405ff875a556fead1444c1f10b68582 - Read/Download File
De Novo Peptide Sequencing by Nanoelectrospray Tandem Mass
De Novo Peptide Sequencing by Nanoelectrospray Tandem Mass Spectrometry ... and high throughput using the accurate masses obtained by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry peptide mapping (2). ... Mann M. and Wilm M. (1994) Error tolerant identification of peptides in sequence ...
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A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomics
A new matrix-assisted laser-desorption/ionization time-of-flight/time-of-flight mass ... different modes of dissociation: laser-induced dissociation (LID) and high- energy ... (MALDI-TOF MS) provides a good high throughput compatibility [1, 6] and a ... and decreases with increasing mass tolerance and chemical heterogeneity.
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Automated de novo sequencing of proteins by tandem high
complete except for the tandem MS-resistant region K13–V20 that contains the ... niques such as matrix-assisted laser desorptionionization (5) ... (31–35), induces far more general backbone cleavage through ... (41) using nanoelectrospray ionization (30, 42). ..... tion and this algorithm shows promise for high-throughput.
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Mass spectrometry in nucleic acid, carbohydrate and steroid analysis
Example data obtained from the high throughput MALDI-TOF-MS analysis of single ... Electrospray ionization (negative ion) mass spectrum of an oligonucleotide. ... In a set of simple experiments using an ESI collision-induced dissociation (CID) ... more challenging to interpret due to the background matrix interference in.
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Full-Text PDF - MDPI
May 25, 2016 ... mixtures encountered in high throughput metabolomics applications . ... techniques like collision induced dissociation (CID), higher-energy collisional dissociation (HCD), ..... defined mass tolerance window. .... from biological matrices by direct infusion nanoelectrospray ionization after clean-up on a ...
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Automated de novo Sequencing of Proteins by Tandem High - jstor
complete except for the tandem MS-resistant region K13-V20 thai contains the ... niques such as matrix-assisted laser desorption/ionization (5S ... (31-35), induces far more general backbone cleavage through ... (41) using nanoelectrospray ionization (30, 42). ...... tion and this algorithm shows promise for high-throughput.
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Journal of Chromatography B High-throughput shotgun lipidomics
Feb 24, 2009 ... High-throughput shotgun lipidomics by quadrupole time-of-flight ... automated sample infusion by mircofluidic-based nanoelectrospray ionization, and quantitative multi- .... Abbreviations: CE, cholesteryl ester; CID, collision-induced .... species in various sample matrices (e.g. cells, tissue homogenates.
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PDF (853 KB) - Annual Reviews
Jan 14, 2015 ... Although not yet at the level of high-throughput .... First, activation of the matrix gives rise to a hot plume carrying highly ionized matrix .... Nano-electrospray ionization (nano-ESI) is a variant of ESI that requires ... tolerant to the presence of salts in the protein solution and can be used with aqueous solutions.
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