Hematologic remission and cytogenetic improvement after treatment
Hematologic Remission and Cytogenetic Improvement. After Treatment of Stable- Phase Chronic Myelogenous. Leukemia With Continuous Infusion of.
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Fall 2008, Vol. 13, No. 2 - MD Anderson Cancer Center
to improve the neutropenia, allowing uninterrupt- ed therapy with ... Response in Phase 2 studies of nilotinib after imatinib failure. Response .... cytogenetic remission at the start of therapy became 100% ... patients treated achieve a hematologic response in all phases of ... 1-2 years if stable complete cytogenetic response.
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Treatment of Philadelphia Chromosome-Positive Early Chronic
hematologic and cytogenetic response in patients with. Philadelphia ...... al: Hematologic remission and cytogenetic improvement after treatment of stable- phase.
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Get PDF (115K) - Wiley Online Library
Evaluation of cytogenetic response was available in 29/65 patients. A ... improve remission rates. ... the disease by prolonging the chronic phase and to improve ... cytarabine to IFN-a2b to treat patients with Ph-positive CML ..... improvement after treatment of stable-phase chronic myelogen- ... Annals of Hematology, 72,.
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jan. 13, 1994 - New England Journal of Medicine
Jan 13, 1994 ... logeneic bone marrow transplantation were treated with interferon aifa-2b ... phase of the disease."2 This ... Six of the eight patients with stable CML after relapse had .... according to the patient's tolerance and hematologic response. Rea- .... response had a complete cytogenetic remission ac- cording to ...
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Interferon Alfa-2b Combined with Cytarabine versus Interferon Alone
Jul 24, 1997 ... Hematologic remission and cytogenetic improvement after treatment of stable- phase chronic myelogenous leukemia with continuous infusion ...
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Chronic Myelogenous Leukemia
The treatment options for chronic myelogenous leukemia (CML) ... In the treatment of chronic phase CML, imatinib pro- duces much better hematological and cytogenetic responses than ..... improvement in time to disease progression and survival.23 ..... togenetic response or molecular remission after a speci- fied period of ...
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The CML Guide - Leukemia & Lymphoma Society
research for cures, programs and services to improve the quality ... Finding the Right Doctor. Chronic Phase CML Treatment Goals. Treatment ..... O Restore the body's ability to make healthy blood cells after high-dose .... the terms hematologic, cytogenetic or molecular response (remission). .... same (stable disease).
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Chronic Myeloid Leukemia - Leukemia & Lymphoma Society
Director, Children's Center for Cancer and Blood Disorders, Hematology/ Oncology. Co-Director .... for policies and laws to speed new treatments and improve access to quality medical care. ..... and other tests to determine the extent and stability of cytogenetic and molecular ... phase after failure of interferon-alpha therapy.
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Hematologic improvements in a myelodysplastic syndromes with
We here reported the successful response of a MDS-F patient treated with azacitidine. ... 2006 criteria after 8 cycles of the azacitidine treatment, and complete remission ... A cytogenetic examination of bone marrow cells by G- banding analysis .... hematological improvement-neutrophil, ND: no data, SD: stable disease, CR: ...
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with imatinib mesylate in patients with imatinib resistant chronic my
Jun 21, 2010 ... imatinib-resistant chronic phase chronic myeloid leukemia (CML) patients. ... hematologic and cytogenetic improvement. Oblimersen was ... did not achieve complete cytogenetic remission after ... treatment interventions to patients who achieved ... received a stable dose of imatinib of 600 mg/day for.
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Transplantation for chronic myelogenous leukemia - HEP
the upfront treatment of chronic myelogenous leukemia. (CML) has ..... either cytogenetic relapse or stable-phase hematologic ... cytogenetic remission. Thus ...
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Treatment of Ph+ chronic myeloid leukemia by gamma interferon
The clinical, hematologic and cytogenetic effects of human recombinant ... Only patients in stable chronic phase responded. ... Eight out of nine responding patients remained in remission throughout the duration of treatment (30 to 35 weeks). ... after failure of single interferon therapy in chronic myelogenous leukemia.
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Failure of a non-authorized copy product to maintain - Springer
Apr 29, 2009 ... achieved with imatinib in a patient with chronic phase chronic ... Within three months of initiation of treatment with the copy ... of a previously stable response, with the risk of progression to ... therapy, full hematologic and cytogenetic remission, ... ment failure after the start of imatinib therapy were 3.3%.
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Ausgabe A - Deutsches Ärzteblatt
Results: In a clinical phase 3 trial of imatinib treatment ... remission again after switching to one of the new tyrosine ..... stable, complete molecular response leads to relapse in ..... Gutterman JU: Hematologic remission and cytogenetic improve-.
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A limited number of 5-azacitidine cycles can be effective treatment in
Apr 30, 2010 ... complete remission (CR), marrow CR, or stable disease with ... normalized in 6.3 % of patients while hematologic improve- ... responding patients was 45 weeks, while AML occurred after ..... Pre-treatment cytogenetic characteristics are shown in .... randomized phase II/III trials published for 5-AZA as well.
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Imatinib for Chronic Myeloid Leukemia - Journal of the National
Mar 21, 2011 ... lenged researchers trying to improve treatment options for cancer patients. ... in the treatment of chronic phase chronic myeloid leukemia (CML) remains the ... Effects (ILTE) study assessed overall survival, loss of cytogenetic remission .... cytogenetic remission in patients with chronic myeloid leukemia after.
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Download as a PDF - CiteSeerX
After the initial target of therapy, complete cytogenetic response (CCR), is achieved, ... journey from diagnosis to stable response remains a ... hematologic response [CHR] and transformation to acceler- ..... patient that, despite the use of the term “remission,” the ... variable efficacy in patients treated in chronic phase after.
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Working Group (IWG) response criteria in myelodysplasia - Adelphi
Apr 11, 2006 ... leukemia (AML).1,2 Clonal cytogenetic abnormalities can be identified in .... The IWG criteria define 4 aspects of responses based on treatment ... response, (3) hematologic improvement (HI), and (4) QOL.7 These ... The criteria for complete remission (CR) and partial remission ..... Relapse after CR or PR.
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NCI First International Workshop on the Biology, Prevention, and
Relapse has become the major cause of treatment failure after allogeneic .... overt relapse may improve outcome of alloHSCT for ... stable over the years, although the negative impact of ... Complete Hematologic Remission (must be confirmed by .... Molecular relapse progressing into cytogenetic or hematologic relapse.
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