Cancer Cell Metabolism: One Hallmark, Many Faces - Sabatini lab
Sep 25, 2012 ... ABSTRACT Cancer cells must rewire cellular metabolism to satisfy the ... meet the energetic requirements of maintaining homeostatic .... additional molecular components of this pathway are reviewed ... (B) HIF induces the expression of various glucose .... growth factors or intracellular sterol levels ( 58 ).
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Lipid metabolism in cancer - Wiley Online Library
MINIREVIEW .... Regulation of lipid metabolism by oncogenic signalling pathways. Many cancer cells show high rates of de novo lipid synthesis. ... energy levels and prevents lipid synthesis and stimulates b-oxidation through inhibition of ACC. ... T cells as an example). ...... mRNA expression in some normal and malignant.
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Metabolic Transformation in Notch-DrivenAcute - Sci Forschen
Jan 10, 2016 ... Mini Review ... clinical features, including an increase in the level of circulating white ... The malignant transformation process of T-cells is very complex. It ... activating mutations leading to the upregulation of Notch1 pathway are .... TAN-1, the humanhomolog of the Drosophila notchgene, isbroken by.
[ IJMBM-1-102.pdf - Read/Download File
Coordinate stabilization of growth-regulatory transcripts in T cell
This pathway plays an important role in regulating cell growth and the ... Abnormal transcript expression in malignant T cell lines ... regulators of apoptosis and intracellular signaling, components of energy metabolism, and structural components. ... Many T cell transcripts that are regulated at the level of mRNA decay contain ...
[ 1-s2.0-S0888754305001278-main.pdf?_tid=542eee96-413a-11e4-962e-00000aab0f01&acdnat=1411268130_67ebe5cec187e0721a989a839a1f76f9 - Read/Download File
Review Article Lipid metabolism in prostate cancer - American
Jul 15, 2014 ... Abstract: The malignant transformation of cells requires adaptations ... the energy required for their increased rate of proliferation. ... Exploitation of the alterations in lipid metabolic pathways in prostate ... increase levels of oxygen consumption in order .....  Yue S, Li J, Lee SY, Lee HJ, Shao T, Song B,.
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Mini-Review - Intractable & Rare Diseases Research
Sep 8, 2015 ... expression in malignant tumor tissues is significantly higher than that in ... Mini- Review ... and T-cell leukemia results in higher levels of LAT1 ... rapamycin ( mTOR) signaling pathway, which plays an important role in protein synthesis and energy supply ... oxygen and to dispose of metabolic waste products.
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Tumor suppressors and cell metabolism: a recipe for cancer growth
this review, we consider the potential role of tumor suppressors as ... changes in pathways of energy metabolism and nutrient ... challenge for malignant cells. ..... tially toxic levels of ammonia during c-Myc-dependent ..... murine splenic leukocyte responses to T and B cell mitogens. ... Minireview: The AMP-activated protein.
[ 37_Citric-Acid-Cycle_Cancer-Growth.pdf - Read/Download File
Targeting glucose metabolism for cancer therapy - The Journal of
metabolic changes exhibited by tumor cells is an increase in glucose metabolism ... In this minireview, we discuss the benefits that high levels of glycolysis.
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Tumor cell metabolism
Jun 22, 2011 ... metabolism is presented, showing how metabolic pathways ... allowing malignant cells to self-stimulate growth and proliferation.8 ... In contrast, b-oxidation of fatty acids is ... In mammalian cells, glucose is the preferred substrate for energy- .... proliferating tumor cells require high levels of ATP for growth.
[ cbt.12.11.18140 - Read/Download File
Full-Text PDF - MDPI
Mar 25, 2016 ... Review. Mitochondrial Redox Signaling and. Tumor Progression ... Low level of ROS functions as signaling messengers promoting ... Mitochondria are the organelles to produce energy via oxidative ... connection between redox and metabolic pathway in cancer cells is hypoxia-inducible factor 1α. (HIF-1α) ...
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Metabolic regulation and redox activity as mechanisms for
Jun 23, 2009 ... MINI REVIEW. Metabolic regulation and ... energy metabolism through a redox- regulated code. The redox ... cell death while curbing tumor inflammation and angiogenesis, ... inflammation and angiogenesis, survival signaling pathways, ... dysregulation at the whole body level by dietary phytochemicals.
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minireview - Molecular and Cellular Biology - American Society for
MINIREVIEW c-Myc Target ... haps arose from somatic hypermutation in B cells, cluster in .... study has provided evidence that endogenous levels of c-Myc ..... target genes is involved in biosynthetic and metabolic pathways ... increase in c- Myc expression during normal T-lymphocyte mi- ..... to glycolytic energy production.
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Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling*
Oct 21, 2014 ... *This is the fifth article in the Minireview Series on the Thirtieth Anniver- ... metabolic reprogramming in cancer cells meets energetic demands ...
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Sirtuins, metabolism, and cancer - Frontiers
Feb 21, 2012 ... MINI REVIEW ARTICLE ... Here, we specifically review recent progress on the role of sirtuins in DNA ... Cells become malignant by the acquisition of a succession ... tive phosphorylation to produce energy from glucose, cancer cells .... indicating the main DNA repair and metabolic pathways regulated by ...
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The Monocarboxylate Transporter Family—Role and - Bris.ac.uk
Critical Review. The Monocarboxylate ... lactate, and the ketone bodies ( acetoacetate and b-hydroxybuty- rate) across the ... ure 1 summarizes the key metabolic pathways requiring such .... mediated by MCT1 in some cases, (e.g., red blood cells and T- .... cle as levels of exercise increase, the pH of the muscle will drop and ...
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Short Chain Fatty Acids (SCFA) Reprogram Gene Expression - Plos
Jul 21, 2016 ... Human Malignant Epithelial and Lymphoid Cells. ... the cellular metabolism, thus affecting cell energy status and signaling ... ted effect of butyric acid involving several important host cell signaling pathways. .... Short chain fatty acids induced EBV lytic cycle in B-cell lymphoma and ..... Physiological Reviews.
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The role of autophagy induced by tumor - Springer
In this review, we discussed the interaction between autophagy and the tumor microenvironment and ... cancer cell niche is called the tumor microenvironment,.
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Nutritional and physiological consequences of tumour glycolysis
transporter levels, shifts of the isoenzyme patterns in the cancer cells to those similar to foetal ..... Effect of tumour glycolysis on overall host energy metabolism.
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metabolic microenvironment of tumor cells: a key factor in malignant
In this mini-review, the consequences of the irregu- lar structure ... of the « metabolic» microenvironment such as energy ... as a driving force in malignant progression: ... oxygen-sensitive signaling pathways have also been ... (4) At the cell population level, severe hypoxia can .... Sonveaux P, Vegran F, Schroeder T, et al.
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AMPK and cell proliferation â•ﬁ AMPK as a therapeutic target for
Apr 13, 2006 ... non-malignant cells as well as in tumour cells. These actions of AMPK appear to be ... review, we focus on the effect of AMPK activation on.
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