Elevated expression of interleukin-7 receptor in inflamed joints
Inflamed Joints Mediates Interleukin-7–Induced ... tional ability of the high-affinity interleukin-7 receptor ... synovial tissue, and the level of IL-7R expression.
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The Novel Role of IL-7 Ligation to IL-7 Receptor in Myeloid Cells of
To our knowledge, we show for the first time that expression of IL-7/IL-7R in myeloid ..... Because expression of IL-7 and IL-7R is elevated in RA compared ..... pression of interleukin-7 receptor in inflamed joints mediates interleukin-7- induced.
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Interleukin-7-aggravated joint inflammation and tissue - Springer
Jun 7, 2012 ... IL-7 increased arthritis severity and radiology-assessed joint destruction. .... Additionally, IL-7 stimulates T-cell-dependent expression of co-stimulatory ..... receptor in inflamed joints mediates interleukin-7-induced immune ...
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Interleukin-7 in rheumatoid arthritis - Rheumatology
Mar 20, 2008 ... However, IL-7 in the joint may have a more sinister role, contributing to a vicious cycle perpetuating inflammation. Typically, IL-1 and ... high level of expression in the RA synovium and SF . IL-7 was first identified for ...... 52 Mazzucchelli R, Durum S. Interleukin-7 receptor expression: intelligent design. Nat.
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IL-7 receptor α expressing B cells act proinflammatory in collagen
Mar 16, 2013 ... well as the interleukin (IL)-7/IL-7 receptor (IL-7R) system play a role in ... this effect. Expression of IL-7Rα is increased when B cells ..... interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation ...
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Increased interleukin (IL)-7Rα expression in salivary glands of
Feb 6, 2012 ... and IL-7Rα cells in inflamed LSG of patients with pSS .... Figure 1 Increased expression of interleukin 7 receptor α (IL-7Rα) in CD3 T cell-rich ..... interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune.
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Intraarticular soluble interleukin17 receptor levels are increased in
which they documented increased expression of interleukin-7. (IL-7) and IL-7 .... receptor in inflamed joints mediates interleukin-7–induced immune activation in ...
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Interleukin-7-aggravated joint inflammation and tissue - Springer
Jun 7, 2012 ... Interleukin-7-aggravated joint inflammation and ... Results: IL-7 increased arthritis severity and radiology-assessed joint ... vial tissue, IL-7 is abundantly expressed by macro- ... IL-7 effects are mediated through the IL-7 receptor-a ...... Hartgring SA, Bijlsma JW, Lafeber FP, van Roon JA: Interleukin-7 induced.
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van Roon J et al, 2010 - Dendritics
Oct 13, 2014 ... Numbers of CD4 T cells expressing either CD25 or CD127, and those co- expressing or lacking both CD25 ... the high-affinity IL-7 receptor-α chain (IL-7R; CD127) in ..... inflamed joints mediates interleukin-7-induced immune.
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Increased IL-7 Expression in Vogt-Koyanagi-Harada Disease - IOVS
binant IL-7 induced significant cell proliferation and secretion of IL-17 and IFN- by ..... Elevated expression of interleukin-7 receptor in inflamed joints mediates.
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The Discovery of Novel Experimental Therapies for Inflammatory
Dec 21, 2009 ... Mediators of Inflammation ... few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, .... would be evidence for elevated levels of IL-7 in the synovial ... cell expansion but upregulation of IL-7 gene expression in ...... joints mediates interleukin-7-induced immune activation in.
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Interleukin 7-induced lymphoid neogenesis in arthritis: recapitulation
It is primarily expressed by epithelial and ... IL-7 interleukin 7. IL-7R interleukin 7 receptor. JAK3 janus-activating kinase 3. LN lymph node ... leukocytes is mediated by the collaboration of ex- tracellular .... dritic cells, lymphatic vessels and high endothelial venules. ... chronic inflammation of the joints leading to pro- gressive ...
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Integrated Analysis of MicroRNA and mRNA Expression Profiles in
Elevated expression of interleukin-7 receptor in inflamed joints mediates inter- leukin-7-induced immune activation in rheumatoid arthritis. Arthritis Rheum 2009 ...
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Prostaglandin Mediates IL-23/IL-17-Induced Neutrophil - jstor
IL-1 7-induced neutrophil migration was not affected by COX in- ... bers of IL-17- expressing cells and increased levels of cytokines ... previously that intra-articular (tibiofemoral joint) injection of ..... We did not identify the PGE2 receptor that operates this ..... inflammation, hyperalgesia, and interleukin 6 production in vivo.
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Proinflammatory mediator-induced reversal of CD4+,CD25+
CD4,CD25 Regulatory T Cell–Mediated Suppression in Rheumatoid Arthritis ... characterized by chronic joint inflammation. The inflam- ... high levels of TNF and interleukin-1 (IL-1) upon interaction with T ..... IL-7–induced reduction of the suppressive func- tion of CD4 .... mechanisms. Since IL-7 receptor (IL-7R) expression.
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Harnessing the biology of IL-7 for therapeutic application - Cancer
mediated signalling through the induction of expression of SMAD ... primates and humans results in widespread T cell proliferation, increased T cell numbers, modulation of .... Interleukin‑7 (IL‑7) signals through the IL‑7 receptor (IL‑7R), a heterodimer comprised of ...... the severity of joint inflammation in mouse models114.
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Regulation of Articular Chondrocyte Phenotype by Bone
Morphogenetic Protein 7, Interleukin 1, and Cellular Context ... cytes induced increased expression of four cytoskel- etal proteins: ... threonine kinase receptors . ... Murine knee joint cartilage was placed into 0.5% trypsin and incu- ..... mediating BMP 7-induced expression of tensin, talin, ..... Cytokines and inflammation in.
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The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 - Plos
Jun 25, 2015 ... The cytokines interleukin (IL)-7 and thymic stromal lymphopoietin ... cultures, TSLP and IL-7 additively increased T-cell proliferation and ... arthritis in mice linked with enhanced inflammation and immuno- ... target cells while signalling through the same receptor subunit, ..... 7-mediated immune responses.
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TSLP - Journal of Leukocyte Biology
Mar 21, 2012 ... ment . Like IL-7, TSLP can stimulate thymocytes and pro- ... Chemoattractant receptorhomologous molecule expressed on Th2 lym- .... challenge phases of FITC-mediated CHS, as ear swelling was ... Increased expression of TSLP in ..... of a functional heteromeric complex requires interleukin 7 receptor.
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Increased Blood Levels of Growth Factors, Proinflammatory - Plos
Dec 4, 2015 ... matory and Th1 cytokines, such as interleukin (IL)-1β, IL-2, IL-6, IL-12, tumor necrosis factor. (TNF)-α, and .... IL-7. High Sensitivity Human Cytokine. 0.12 pg/ mL. 100%. IL-1β ..... In these T cells, IL-7 maintains the expression of FoxP3 and .... and biomarkers of inflammation in patients with type 1 diabetes.
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