Nitric oxide is involved in arsenite inhibition of - Carcinogenesis
species and nitric oxide are involved in arsenite toxicity. and tumor ... the effect of arsenite on the expression of UV-irradiated ... potential of arsenic compounds. ...... proliferation and nitric oxide synthesis in C3H 10T 1/2 murine fibroblasts.
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Arsenic - OEHHA
pounds demonstrated that exposure to inorganic arsenic compounds. · DNA, and produce ... toneal cells was suppressed but there was no observed effect on. NK cytotoxicity (Vos ... antigen, atrazine induced elevations in T-cell proliferation, cytolytic activity, and ..... tosis in cardiac myocytes: The role of inducible nitric oxide.
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Mechanism of arsenic carcinogenesis: an integrated approach
since these compounds can have different effects, both genotoxic and non- genotoxic. This review will try ... clear that high dose exposure to arsenic compounds.
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HIV, Cardiovascular Diseases, and Chronic Arsenic - arXiv.org
arsenic exposure, and its possible impact on the accelerated HIV/ART ... oxide; NOS, nitric oxide synthase; eNOS, endothelial nitric oxide synthase; ROS, .... arsenic compounds are then sublimated through rain and thereby percolate into drinking .... thereby induce proliferation response in vascular smooth muscle cells .
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Arsenic: toxicity, oxidative stress and human disease
most common oxidation numbers of arsenic are +5, +3 and −3, in ... ganic arsenic compound which may also impact adversely on ..... induce de novo synthesis of HO1 in human lymphoblastoid cells, ... initiate the generation of reactive nitrogen species (RNS). ..... stress, enhanced cell proliferation and modulation of gene.
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Download PDF - French Sciences Publishing Group
Feb 5, 2016 ... Recent development in arsenic speciation and toxicity reduction of inorganic arsenic in food. Long Chen* .... As (III) is a protoplastic poison due to its effect on sulfydryl ... with certain cell compounds like protein kinase C (PKC) ... Arsenic could enhance cell proliferation, nitric oxide ... during ATP synthesis.
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Full-Text PDF - MDPI.com
Feb 5, 2015 ... Curcumin, a polyphenolic compound derived from turmeric. (Curcumin ..... Inducible nitric oxide synthase (iNOS) is an inflammation-induced ... synergistic effect and inhibited the proliferation of RAW 264.7 ..... following pre-malignant high cancer risk conditions were included: urinary bladder cancer, arsenic.
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Modulation of Early Stress‐related Biomarkers in Cytoplasm by the
S and Q. Arsenic caused loss of the cellular viability in a time-dependent manner. ... compounds can be used as cancer chemotherapeutic agents ... therapeutic use also causes toxicity and adverse effects on ... nitric oxide [nitric oxide, produced by nitric oxide synthase ..... lator of nitric oxide synthesis and vascular function.
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History of the Development of Arsenic Derivatives - The Oncologist
During his time, 500 types of organic arsenic compounds were in ... activity by studying their effects on the metabolism of nor- mal and .... tubulin polymerization, nitric oxide synthesis, and oncogene expression or .... tion of proliferation .
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The two opposite facets of arsenic: toxic and - QScience.com
Mar 7, 2013 ... Arsenic compounds have paradoxical effects: they are threatening to .... cellular energy pathways as well as in DNA synthesis and repair.1,33,3,5 No .... DNA methylation and interactions with growth factors or cell proliferation. ..... Zeng Y. Mitochondria, calcium and nitric oxide in the apoptotic pathway.
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Arsenic inhibits in vitro spermatogenesis and induces germ cell
The precise mechanism and direct effects of arsenic on fish, particularly in reproduction, are not well clarified. .... the low-dose arsenic effect on 11-KT synthesis in which at ... Figure 3 Effects of arsenic on hCG-induced germ cell proliferation ..... Calderon-Aranda ES 2004 Nitric oxide and superoxide anion production.
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Arsenic Exposure and Cardiovascular Disorders: An Overview
Sep 29, 2009 ... Both arsenite and arsenate would have similar effects in vivo, as the absorbed ... and aggregation, smooth muscle cell proliferation and migration [14, 17]. ... which occurs mainly due to reduction in the synthesis and release of NO, ..... Nitric oxide -dependent endothelial function and cardiovascular disease.
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Synergistic Anti-Tumor Effects of Combination of Photodynamic
Jun 1, 2012 ... Photodynamic Therapy and Arsenic Compound in. Cervical ... significantly inhibited TC-1 cell proliferation in a dose-dependent manner (P,0.05) by MTT assay. The anti- ... oxide (As4O6) was reported to have antiangiogenic effects on the ..... generate reactive oxygen and reactive nitrogen species to induce.
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SELECTED MECHANISMS OF GENOTOXIC EFFECTS OF
to know the mechanisms of toxicity of inorganic arsenic compounds. In vitro and in vivo ... Some data also suggest that i-As increases celluar proliferation and apoptosis. The purpose of this .... arsenate and to Fowler`s solution (arsenic oxide dissolved in potassium ...... Lynn S, Jan KY. Calcium-dependent nitric oxide pro-.
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hormesis [biological effects of low level exposures (belle)]
dose inhibitory response, also called hormesis, or biological effects of low ... agents, phyto-compounds, as well as endogenous agonists (Calabrese ... activated at low concentrations, which stimulates DNA synthesis and cel- .... Arsenate (iAs ..... Biphasic effect of exogenous nitric oxide on proliferation and differentiation in ...
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Structure and Antioxidant Activity of Polyphenols Derived from Propolis
Dec 20, 2013 ... as well as on the breed of bees, new chemical compounds are sometimes identified ..... Flavonoids present in propolis stop the proliferation of various types of ... have a direct effect on the synthesis of nitric oxide. ..... arsenic trioxide- induced apoptosis in human leukemia cells via reactive oxygen species.
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PDF(287K) - Wiley Online Library
cell influx, synthesis of extracellular matrix (ECM) and cell proliferation can occur. ... Adsorbed genotoxic compounds (e.g., PAHs) can directly damage DNA (6). Finally, upon ... thought to impact both on genotoxicity and cell proliferation. Genotoxic events in .... By virtue of their inducible Nitric Oxide Synthase (iNOS) activity ...
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PDF Version - Environmental Health Perspectives - National
tial of these compounds is poorly understood. ... Translesion DNA synthesis polymerases are ... Genotoxic chemicals can delay cellular proliferation in DNA- repair–deficient ... KEY WORDS: alternative test methods development, arsenic, DNA repair, ..... effect on DNA repair mutant cells. ..... 2004), nitric oxide (Wu et al.
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Full-Text - MDPI
Mar 11, 2011 ... cytokines [5-11]; DNA synthesis; and cell proliferation [2,12-14] . ... platinum containing compounds, alkylating agents (such as melphalan), ... and arsenic [24 ]. ... nitrogen species, such as nitric oxide (·NO)  and the peroxynitrite (ONOO ... intracellular redox status may affect nuclear chromatin remodeling ...
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Invited Reviews - Toxicologic Pathology
Invited Reviews. Carcinogenic and Systemic Health Effects Associated with Arsenic ... than 80% of arsenic compounds are used to manufacture products ... cause the toxicity varies according to its oxidation state, its .... involved in cell growth and proliferation (136). ..... synthesis and excretion at the expense of uroporphyrin.
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