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PDF(627K) - Wiley Online Library
cinogens in living cells. Histochemistry 79:31-52, 1983. Rho J Direct fluorometric analysis of benz4a)pyrene metabolite formation by mouse liver microsomes.
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Species differences in activating and inactivating enzymes related to
Mar 15, 1977 ... It is concluded that species such as mice which possess high ... toxic effects which are mediated by metabolically formed epoxides which ... Epoxide hydratase Benzo(a)pyrene Inactivation Mutagenicity .... inactivating enzymes related to the control of mutagenic metabolites; Journal: Archives of Toxicology
[ m30v0348377v008u.pdf - Read/Download File

Metabolic characterization of cell systems used in in vitro toxicology
We performed a gene expression analysis for 41 metabolism-related genes and ... This is the case for benzo[a]pyrene (B[a]P), a well-known tobacco smoke ... The formation of B[a]P DNA adducts has been reported in vitro using lung .... with a Fluoroskan Ascent® fluorometer (Thermo Fisher Scientific Inc., United Kingdom).
[ 1-s2.0-S0887233313001239-main.pdf?_tid=65c3591a-5d48-11e4-96f4-00000aacb35d&acdnat=1414352805_aa0db213bff2f4c10421ccc3d44ff54f - Read/Download File

Effects of Inducers and Epoxide Hydrase on the Metabolism - JStor
and quantitation of benzopyrene metabolites into three ... the various metabolites formed. ... BP metabolites, direct comparisons of possible metabolites .... Analysis . Extracts from two identical incubations were pooled. Two. milliliter portions of the organic phase ..... products obtained from mouse skin after painting with 3,4-.
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Effects of Inducers and Epoxide Hydrase on the Metabolism of
Aug 12, 1974 ... ... of Benzo[a]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High ... and quantitation of benzopyrene metabolites into three ... crease in the formation of phenolic metabolites, indicat- ... BP metabolites, direct comparisons of possible metabolites ..... Although the fluorimetric assay for.
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8. REFERENCES Aardema MJ, Gibson DP, Kerckaert GA, et al
Gas chromatographic-mass spectrometric analysis of chlorination effects on ... In vivo DNA adduct formation by benzo(a)pyrene in mouse ... A new sensitive fluorometric assay for ... Shpol'skii spectroscopy of benzo(a)pyrene metabolites. ... mutagenicity of direct-acting carcinogens as well as benzo [alpha] pyrene- induced ...
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Biological Activity of Tobacco Smoke and Tobacco Smoke - NCBI
monooxygenase activity, b) inhibit benzo(a)pyrene metabolism in vitro, c) be metabolized to forms ... be both a potential "initiator" and "promotor" of lung cancer in mice, and that this latter property may .... AHH units are expressed as nmole 3-OH-BP formed/min/g ..... fluorometric assay of a microsomal O- dealkylation which is.
[ envhper00474-0065.pdf - Read/Download File

Benzo(a)pyrene Diolepoxide-DNA Adducts Detected by - NCBI
Using benzo(a)pyrene (BP) as a model carcinogen we are currently applying a fluorescence ... formed. Highly sensitive assays are thus needed. The first important ... The fluorometric HPLC assay by Rahn et al. (14) .... Vo-Dinh, T. Multicomponent analysis by synchronous luminesc- ... benzo(a)pyrene metabolites to DNA.
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pyrene by Mouse Lung Microsomes1 - Cancer Research
Jan 3, 1984 ... benzo(a)pyrene (BP) metabolism were studied with lung micro- somes from ... observed inhibitions of BP metabolism in the formation of diol- epoxides .... by the fluorometric method of Dansette ef al. (10). ... For HPLC analysis, a 50-^1aliquot was injected into a Waters Associates ..... The direct inhibitory.
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Detection of DNA–protein crosslinks (DPCs) by novel direct
Jun 22, 2012 ... metabolite of 1,3-butadiene (25). In DPCs ... removal of genomic DPCs formed by various DNA- damaging ... fluorometric analysis and western blotting analysis using anti-FITC ... cultured cells and transplanted mouse tumors exposed to ...... inhibition and DNA damage induced by benzo[a]pyrene and.
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Influence of -Naphthoflavone on 7,12-Dimethylbenz(a)anthracene
May 11, 2000 ... those formed in mouse embryo fibroblasts, and levels of DMBA-. DNA adducts ... activation to DNA-binding metabolites in trout liver cells and mouse .... separation and fluorometric analysis of the resultant DMBA hydroxylation .... DMBA or 0.1 g/ ml [3H-benzo(a)pyrene for 24 h. .... Direct comparisons of the.
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Metabolic competence and susceptibility of - Carcinogenesis
carcinogen metabolism and susceptibility to genotoxic injury are ... Enzyme induction and DNA adduct formation were also assessed ... Benzo[a]pyrene induced GSTA3 and UGT in regeneration vs Cyp1A .... Activity was assessed by fluorimetric ... gestation with care to avoid direct foetal exposure, while post-natal animals.
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The Metabolism of Benzo(a)pyrene by Cytochrome P-450 in
cell lines and in C3H mouse liver and lung. The cell ... by treat- ment with benzo( a)pyrene; .... were both depend- ent upon the intracellular activity of this enzyme. In direct contradiction to these .... Analysis of BP Metabo- lism-The microsomal formation of BP metabolites ... and 522 nm emission by the fluorometric method.
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Multiphoton spectral analysis of benzo[a]pyrene uptake and
Mar 21, 2011 ... and metabolism in vivo in a mouse skin model (Lopp et al., 1986). At the cellular ... single cell multiphoton microscopic analysis of cellular BaP uptake and partitioning in ... the rates of metabolite formation and persistence and also facilitate .... Similarly, direct conversion of BPDE to a pyrene adduct was.
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Cellular Uptake Benzo(a)pyrene and Intracellular Localization of by
lipid volume of isolated mouse peritoneal macrophages was increased by prior .... benzo(a)pyrene entry into cells by direct observation of living ... lipoprotein metabolism on the extent of cell uptake and on ..... Kinetic Measurements and Analysis: Kinetic measurements, ... complicated by the formation of metabolic products.
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Modulation of the metabolism and adverse effects of benzo[a]pyrene
ery of unmetabolized B[a]P and decreased formation of end-point phenol metabolites in two types of target cells. Furthermore, strong antibody reactivity with 7 ...
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Studies with Liver, Lung, Placenta, and Lymphocytes - Toxicologic
of mice it has been demonstrated that AHH .... benzo(a)pyrene metabolites in in vitro incu- ... duct formed is disproportionately large on the .... Direct fluorometric methods for measuring mixed-func- tion oxidase activity. ... Analysis of aryl.
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DNA Damage from Polycyclic Aromatic Hydrocarbons Measured by
compare the levels of benzo[a]pyrene-DNA adducts as a .... adequate quantity and quality for analysis. ... The subset in the present analysis did not differ .... threshold for adduct formation and that adducts generally ... differences are generally found, few studies have found a direct .... Assessment of metabolites and AhR.
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Cultured mouse embryos metabolize benzo[a]pyrene - Europe PMC
provide direct evidence that genetically responsive mouse em- ... proach is based on the quantitative analysis of sister chromatid ... metabolism of benzo[a ] pyrene and any subsequent effects on .... pendent increases in SCE formation in all three genetically ..... they cannot be detected by conventional fluorometric, radio-.
[ pnas00493-0466.pdf - Read/Download File

Macromolecular Binding of 3H-Benzo(a)pyrene Metabolites and
Metabolites and Lymphocyte Transformation in Patients ... The binding of 3H- benzo(a)pyrene metabolites to macromolecules was evaluated in .... The fluorometric ... direct measures of the metabolites of benzo(a) ... that previously reported for mouse embryo cells in .... groups by analysis of variance (F test, P = 0.3).
[ arrd.1979.120.2.369 - Read/Download File

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