dexamethasone synchronizes asthmatic respiratory epithelium repair in vitro

Asthmatic Airway Epithelium Is Intrinsically Inflammatory and
They were pulsed with dexamethasone (20 nM) or vehicle for 2 hours at 226 ... Asthmatic epithelia showed 40% fewer BrdU1 cells at 148 .... An in vitro epithelial injury model that allows for the study of epithelial repair processes in the lung was adapted for use in this study (16–18). ..... epithelium to synchronize its mitosis.
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PDF (822 KB) - ATS Journals
Mar 24, 2014 ... cultures were mitotically synchronized at 12 hours off-set and then combined, the ... M) in vitro, asthmatic epithelial basal cells proliferate with a ...
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PDF (165 KB) - Critical Reviews in Oncology/Hematology
Mortality rate: lung cancer, breast cancer, and malignant ..... been shown to exert antitumor effects via vitamin D receptors (VDR) both in vitro and in vivo through ...
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Cell Cycle Arrest by Glucocorticoids May Protect Normal Tissue and
Glucocorticoids (GCs) such as dexamethasone (DEX) are of great value in the treat- ment of inflammatory disorders, such as rheumatoid arthritis, asthma and dermatitis, autoimmune ... Hofmann et al.25 found that human lung cancer cell lines respon- ... lymphomas, and multiple myeloma.34 In contrast, cells of epithelial.
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Pharmacological Strategies in the Prevention and Management of
exposure to toxic oxygen levels, and ventilator-induced lung injury, resulting in arrested ... such as fibrosis, epithelial metaplasia, and scarring.1 The ..... have been used to relieve bronchospasm in asthmatic pa- ... evaluated effects of early treatment of dexamethasone on the ..... vention and repair of neonatal lung injury.
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Anaphylactic Reaction With Avitene: A Pediatric Case - AANA.com
with bone graft from an iliac crest repair of an oral nasal fistula. ... of dexamethasone (Decadron) were given IV through an ... PACU, the patient was placed on synchronized intermit- ... antigen, epithelial or endothelial barriers are invaded, ... Respiratory arrest .... unexplained cases of brain injury.20 Extensive in vitro.
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Glucocorticoids and Circadian Clock Control of Cell Proliferation - Hal
Nov 10, 2011 ... Since previous work had shown that DNA damage repair may also be .... receptor agonist dexamethasone can phase shift rhythmic gene .... reduced gluconeogenic gene expression in the liver, a lack of in vitro T cell apoptosis .... epithelial origin (e.g. cells of the mammary gland or lung epithelial cells, see ...
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CC and CXC Chemokines Induce Airway Smooth Muscle
epithelium; however, chemokines have other biological effects. The objective of ... tribute to airway remodeling seen in asthma by enhancing the number and survival of ASMCs. ... tumor cells as was shown in small lung cell carcinoma and breast .... mented with 0.5% FBS) for 48 h to induce quiescence and synchronize the.
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Regulation of Activin A Expression in Mast Cells and Asthma: Its
lung MC from patients with asthma by double-immunofluorescence staining. Furthermore, secretion of ... thesis of ECM and growth factors in fibroblasts and epithelial cells. (12, 13). ... important role of activin A in the inflammatory and repair pro- .... growth-arrested cells were used because cells can be synchronized in the.
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PDF (393 KB) - ATS Journals
Departments of Pharmacology and Paediatric-Respiratory Medicine, Erasmus University, ... epithelial shedding, basement membrane thickening, and ... vitro and in mild asthmatics in vivo, thus suggesting a ... tion in tissue repair after injury or act as a regulatory pep- ..... tions in order to synchronize and growth-arrest human.
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Full-Text - MDPI
May 25, 2010 ... adhesion of microbial pathogens to respiratory epithelium, ... following exposure of bacteria to bactericidal agents in vitro, or in animal models of experimental .... panbronchiolitis, refractory asthma, and bronchiolitis obliterans syndrome, ... administration of these agents may need to be synchronized with the ...
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PhD thesis Alteration in the Wnt microenvironment directly regulates
2.4.2 Epithelial repair mechanisms in the lung . ..... (asthma), exposure to xenobiotics for example cigarette smoke, physical trauma. (mechanical ventilation) ... In vitro studies have confirmed the role of ATII cells in alveolar regeneration ..... cultured in adipogenic differentiation medium containing insulin, dexamethasone and.
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Inflammation resolved by retinoid X receptor-mediated inactivation
oids are positive CYP4F regulators in vitro, effecting increased leukotriene B4 ... liferative dermatoses—an innate mechanism to repair and restore epidermal ...
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Regulation of Retinal Inflammation by Rhythmic Expression of MiR
Aug 16, 2013 ... synchronized with dexamethasone. Expression of miR-146a, .... retinal pigment epithelial cell line ARPE-19 cell culture (HRPE) cells and HMC ...
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Tip60 functions as a potential corepressor of KLF4 in regulation of
Sep 7, 2007 ... that specific ablation of KLF4 in the gastric epithelium of mice results ... expressed Tip60 to purified Tat in vitro (16). Tip60 belongs ... in DNA repair and apoptosis (18). While Tip60 ... lung cDNA library from Clontech (Catalog number. HL4044AH) ..... and how these proteins synchronize to protect the cells. It.
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Annual Meeting Abstracts - American Federation for Medical Research
are linked to more respiratory morbidity in premature children during the first ... derived epithelium in vitro induces basolateral secretion of TGF-A1. We ... relationship between epithelial repair processes and airway remodeling in an in vivo model. Methods Used: Human airway epithelial cells from asthmatic and non -.
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Inflammation resolved by retinoid X receptor - Life Sciences
Sep 20, 2007 ... oids are positive CYP4F regulators in vitro, effecting increased ... liferative dermatoses—an innate mechanism to repair ... eases, including asthma, atopic dermatitis, reperfusion injury ... pair and epithelial closure phase is characterized tem- ... specified; 10 M dexamethasone; 30 M -naphthoflavone;.
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Open Access
Feb 5, 2013 ... inflammatory, and allergic disorders, such as asthma, rheumatoid arthritis ... dexamethasone and prednisolone. Despite their ..... Intestinal epithelial cells. (59 ) ... Wound repair. Required ..... vitro, GILZ small interfering RNA inhibited the suppres- ... induced lung fibrosis, and dextran sodium sulfate -in-.
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New Insights into the Anti-inflammatory - Endocrine Society
Feb 5, 2013 ... inflammatory, and allergic disorders, such as asthma, rheumatoid arthritis ... dexamethasone and prednisolone. Despite their ..... Intestinal epithelial cells. (59 ) ... Wound repair. Required ..... vitro, GILZ small interfering RNA inhibited the suppres- ... induced lung fibrosis, and dextran sodium sulfate -in-.
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