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Dermatofibrosarcoma protuberansderived fibrosarcoma: Clinical
Dermatofibrosarcoma protuberans-derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib. Silvia Stacchiotti1, Florence Pedeutour2, ...
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Evolution of Dermatofibrosarcoma protuberans (DFSP) - Molecular
Jul 1, 2016 ... fibrosarcoma (FS-DFSP): an event marked by epithelial mesenchymal ...... protuberans-derived fibrosarcoma: clinical history, biological profile.
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Neoadjuvant treatment of Dermatofibrosarcoma Protuberans of
Aug 6, 2014 ... from DFSP treated with neoadjuvant Imatinib and subsequently R0 ..... protuberans-derived fibrosarcoma: clinical history, biological profile and.
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Treatment of Dermatofibrosarcoma Protuberans - Enliven Archive
May 18, 2015 ... Treatment of Dermatofibrosarcoma Protuberans with Imatinib before ... translocation displacing the promoter of the collagen type1 α1 next to the platelet- derived growth .... of the clinical features and treatment overview of these patients is provided ..... history, biological profile and sensitivity to imatinib.
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clinical practice guidelines - Annals of Oncology
with dermatofibrosarcoma protuberans who are not amenable ..... protuberans- derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib.
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Histology-and non-histology-driven therapy for treatment of soft
found its targeted therapy: dermatofibrosarcoma protuberans. [28]. This is .... derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib.
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Download - Chinese Clinical Oncology
histopathological and molecular biological features that are ... It concluded that imatinib is active against DFSP, although there was no .... reflect natural history and not drug effect. ..... Dermatofibrosarcoma protuberans-derived fibrosarcoma:.
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Dermatofibrosarcoma: a rare form of soft tissue - Chirurgia
Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue tumor of ... on cytogenesis and molecular biology of the tumor, so new therapeutic ... There was no history of trauma ... lymph nodes were not enlarged, while the rest clinical exami- ... Recently, giant cell fibrosarcoma (GCF) is considered as the juvenile ...
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A CD117 and CD34 Immunoreactive Sarcoma Masquerading as a
CD117 and CD34 suggestive of GIST, but the clinical picture was unusual for GIST. Mutational analyses for KIT and platelet-derived growth factor receptor alpha (PDGFRa) were negative; DOG1 was not .... dermatofibrosarcoma protuberans, inflammatory myofi- broblastic tumor, fibrosarcoma, spindle cell sarcoma not.
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Pediatric Nonrhabdomyosarcoma Soft Tissue Sarcomas
Apr 8, 2008 ... Evaluate the clinical features of NRSTS in pediatric patients. 2. Identify ... about their biology, natural history, or optimal treat- ... atric NRSTSs are dermatofibrosarcoma protuberans, ma- ... peripheral nerve sheath tumor (MPNST ), and fibrosarcoma ... constitutive expression of platelet-derived growth factor B.
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Neck Dissection of the Head and Neck Sarcoma - InTech
Feb 22, 2012 ... Neck Dissection – Clinical Application and Recent Advances. 126 ... an infrequent event in the natural history of soft tissue sarcomas. .... Occasionally, DFSP will undergo transformation to classic fibrosarcoma (Wong et ... visceral angiosarcomas are caused by biological differences or differences in clinical.
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Dermatofibrosarcoma protuberans en el dorso del pie: a propósito
Resumen. El dermatofibrosarcoma protuberans es un tumor de partes blandas poco frecuente, de etiología ..... Dermatofibrosarcoma protuberans-derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib. Int J Cancer ...
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REVIEW Diagnosis and Management of Desmoid Tumors and
KEY WORDS: desmoid; fibrosarcoma; dermatofibrosarcoma protuberans ... The natural history of desmoid tumors is not well-defined and poorly understood. Clinical behavior and therefore, recommended treatments, are often dictated by .... derived growth factor receptors (PDGFR, A and B) and their ligands in desmoid ...
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Targeted Therapies: The Rare Cancer Paradigm - ScienceDirect
One of the weak points of this biological treatment, which by definition is not cytotoxic and can thus ... Chronic myelogenous leukemia (CML): historical outline .... Evidence derived from the clinical experience points out that (i) tumors carrying a ..... Nevertheless, the clinical activity of Imatinib in DFSP suggests a dependence ...
[ B8CWB-4XJP44V-1-T-main.pdf?_tid=dd26461a-3b07-11e4-b4bf-00000aab0f26&acdnat=1410586749_db4f6a2e3cc5d03f0f08d7fbedc0b86f - Read/Download File

Targeted Therapies: The Rare Cancer Paradigm - Elsevier
Article history: Received 15 ... gested for Platelet-derived growth factor beta ( PDGFB) in der- matofibrosarcoma protuberans (DFSP) and, more recently,. Colony stimulating factor 1 ... tential target of therapeutic agents for clinical interventions. Thus, in ... One of the weak points of this biological treatment, which by definition is ...
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EPAR - Scientific Discussion - Variation
Dermatofibrosarcoma protuberans is a rare monoclonal cutaneous soft ... 1( COL1A1) and platelet-derived growth factor B-chain (PDGFβ) gene. ... Both a “ classic” form (most prevalent) and a “high-grade” variant fibrosarcomatous form ( FSDFSP) ... In the submitted documentation, the clinical data that support the claimed ...
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Ph.D Thesis TRANSFORMED DERMATOFIBROSARCOMA - DEA
A small number of cases of DFSP contain areas of fibrosarcoma (FS) or, more rarely ... and the platelet-derived growth factor B-chain (PDGFB) genes. The fusion causes ... role in clinical testing, because it is objective, rapid, cost effective and can ... To investigate the biological behaviour of transformed DFSP by analysing a ...
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Adult-Type Soft Tissue Sarcomas in Pediatric-Age Patients
Jun 20, 2005 ... origin, biology, and natural history, some of which are more ... on the principles derived from the manage- ment of RMS. ... Given the heterogeneity of these tumors, clinical stud- ies should target ... typical of adulthood (excluding infantile fibrosarcoma) and definitely .... Dermatofibrosarcoma protuberans. 3.
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Case Report Atrophic dermatofibrosarcoma protuberans with the
Jun 15, 2015 ... Abstract: Dermatofibrosarcoma protuberans (DFSPs) is an ... of cytogenetic and molecular biology techniques, the detection of fu- ... and platelet-derived growth factor-BB (PDGFB) genes has been ... who had a 2 years history of atrophic DFSPs, and detected the gene ..... matofibrosarcoma protuberans.
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Participants have an implied responsibility to use the newly
Jun 1, 2015 ... subtypes, each with varying clinical phenotypes and behavior. • Some tumors ... Biological potential ... Sclerosing epithelioid fibrosarcoma. •. So-Called ..... Sarcomas Played a Pivotal Historical. Role in the ..... DFSP: dermatofibrosarcoma protuberans ... PDGFRB: platelet-derived growth factor receptor beta ...
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