Control of RUNX3 by histone methyltransferases - Wiley Online Library
Dec 6, 2010 ... Control of RUNX3 by Histone Methyltransferases. You Mie Lee*. School of Life Sciences and Biotechnology, College of Natural Sciences, ...
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Get PDF (498K) - Wiley Online Library
This review discusses the abilities of RUNX proteins, in particular RUNX3, .... mainly through aberrations in DNA methylation, histone ...... Runx3 controls.
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Stabilization of RNT-1 Protein, Runt-related Transcription Factor
Oct 17, 2011 ... RUNX3 family proteins, evolutionarily well conserved tran- scription ...... Lee, Y. M. (2011) Control of RUNX3 by histone methyltransferases.
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The role of EZH2 and DNA methylation in the - Carcinogenesis
silencing of RUNX3 in CRC, but EZH2 and histone methylation are necessary ... carcinogenesis must control whether promoter methylation ultimately occurs (4).
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Dynamic Patterns of Histone Lysine Methylation - Journal of Vision
However, epigenetic control of retinal development is poorly understood. ... their regulators, the histone methyltransferases (HMTases). Ezh2 and G9a, in ..... RUNX3, and promotes tumor progression.57,58 Given the em- bryonic character of ...
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Association of Promoter Methylation of RUNX3 Gene with the - Plos
Sep 17, 2014 ... However, the association between RUNX3 promoter methylation and ..... Lee YM (2011) Control of RUNX3 by histone methyltransferases.
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Full Text (PDF) - Proceedings of the National Academy of Sciences
Dec 29, 2015 ... killer cells through histone methyltransferase activity. Jie Yina,1, Jianmei W. ... NKp; and Helios, Runx3, and Blimp1 for NK cell maturation (15). Although the action .... Ezh2 inhibitors compared with controls (Fig. 3F). Increased ...
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EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer
Nov 18, 2011 ... Histone modifications are thought to control the regulation of genetic programs in .... methylation affects repression of RUNX3, H3K27me3.
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Hyperoxia-induced methylation decreases RUNX3 in a newborn rat
Keywords: DNA methylation, histone methylation, RUNX3, alveolar development, bronchopulmonary .... AT2 cells of the model and control groups, isolated at.
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Causal Relationship between the Loss of RUNX3 Expression and
Runx3/Pebp2αC null mouse gastric mucosa exhibits hyperplasias due to stimulated ... The cell number in the control medium is regarded as 100%. ..... of DNA methyltransferase, and trichostatin A (TSA), an inhibitor of histone deacetylase, ...
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NAOSITE: Nagasaki University's Academic Output SITE
RUNX3 inactivation by histone modification mechanisms… ... RUNX3 inactivation by dual mechanisms of promoter methylation and protein .... RUNX3 interacts with pathways that regulate growth control and differentiation are still obscure.
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hypoxia-associated epimutations as targets for cancer - Springer
Dec 5, 2011 ... dynamic control of histone methylation is thought to reg- ulate chromatin .... cing of the tumour suppressor RUNX3 through histone. H3-lysine 9 ...
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Supplemental Information Characterization of the EZH2 - Cell
Co-expression analysis of histone methyltransferase genes was done by ... for H3K36me2 from stable EZH2 knockdown and vector control MDA-MB-231 cells .... The cdh1 and runx3 genes known to be upregulated upon EZH2 knockdown.
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Download PDF - Plos
Protein level of DNA methyltransferase 3B (DNMT3B) and histone H3K9me ..... comparing with those of the control transfectant and the OAZ transfectant ..... RUNX3 by deletion of DNA methyltransferases leading to caspase independent.
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Opposing Roles of STAT4 and Dnmt3a in Th1 Gene Regulation
Jun 14, 2013 ... transcription factors including Hlx1 and Runx3, activate tran- scription from the ... Epigenetic events that include DNA methylation and histone modification ..... expression in Th1 cells, we transfected WT Th1 cells with control.
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2285-90 c8.27 Jianguo Li.pdf - Asian Pacific Journal of Cancer
Loss of RUNX3 Expression with Human HCC Progression ..... RUNX3 gene, methylation status and clinicopathological ... Control of RUNX3 by histone.
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An ancient Pygo-dependent Wnt enhanceosome integrated - eLife
Aug 27, 2015 ... signaling pathway that controls animal development and stem cell ... to histone H3 tail methylated at lysine 4 via opposite surfaces (Fiedler ..... with ChiLS was also observed for AML1, Runx2 and Runx3 (Figure 5E), consistent with the ...... associates with MLL2 histone methyltransferase and GCN5 histone ...
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Therapeutic Strategies in Gastric Cancer - Journal of Clinical Oncology
Dr Yoshiaki Ito will discuss the role of RUNX3 in the genesis and progression ... cells with inhibitors of methyltransferase, such as 5!-aza- ... growth in gastric cancer may potentially be controlled by inducing ... as histone deacetylase inhibitors.
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3-Deazaneplanocin A (DZNep), an inhibitor of the histone - Hal
May 1, 2015 ... histone methyltransferase EZH2, induces apoptosis and reduces cell .... the chromatin control of stem cell self-renewal and differentiation. [1–7]. They also play ... metastasis suppressor genes, including E-cadherin , RUNX3.
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RUNX3 Is Frequently Inactivated by Dual - Cancer Research
Jul 1, 2006 ... and methylation could render RUNX3 a valuable marker for early .... and breast cancer cell lines. h-Actin served as a loading control. RUNX3 Loss in ... histone deacetylase inhibitors suberoylanilide hydroxamic acid. (SAHA) ...
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