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Tumor necrosis factor‐α augmented tumor response in B16BL6
treatment of solid tumors is limited by its severe, life-threat- ening, toxicity. ... TNF has no anti-tumor effect by itself but augmented drug ...... W, Brouckaert P. Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.
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The Endogenous Balance of Soluble Tumor Necrosis Factor
and Tumor Necrosis Factor Modulates Cachexia and Mortality in Mice Acutely ... in the pathogenesis and lethality of septic shock (2, 56) and cerebral malaria ...
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Safe TNF-based antitumor therapy following - Cloudfront.net
mice showed resistance to TNF-induced lethality, while the tumor ... erties, and its use is often accompanied by unacceptable shock ...... p55TNFR levels were determined with the Quantikine sp55 TNFR .... Bioavailability of recombinant tumor ...
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Safe TNF-based antitumor therapy following p55TNFR reduction in
mice showed resistance to TNF-induced lethality, while the tumor ... erties, and its use is often accompanied by unacceptable shock ...... p55TNFR levels were determined with the Quantikine sp55 TNFR .... Bioavailability of recombinant tumor ...
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Enterocyte-specific A20 deficiency sensitizes to tumor necrosis
Nov 19, 2009 ... NLRs, and cytokine receptors, such as TNF and ...... Bioavailability of recombinant tumor necrosis factor determines its lethality in mice. Eur.
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TREATMENT OF SEPTIC SHOCK WITH THE TUMOR NECROSIS
Jun 27, 1996 ... A recombinant, soluble fusion protein that is ... human tumor necrosis factor (TNF) receptor and the Fc portion of ... its bioavailability.16-19 The plasma concentration of cir- culating ... of antimicrobial therapy were determined in a blinded fashion by a ..... bodies prevent septic shock during lethal bacteraemia.
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Structure-Activity Profiles of Ab-Derived TNF Fusion Proteins
ized wild-type TNF, this construct preserved its IgG1-derived dimeric structure .... molecular mass determination of native immunocytokines was determined with a Superdex ..... Lethality induced by a single i.v. application of effectors in immunodeficient ..... Bioavailability of recombinant tumor necrosis factor deter- mines its ...
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Humira : EPAR - Scientific Discussion
compromises the ability of patients to undertake their activities of daily living and can ... Adalimumab is a recombinant human monoclonal antibody expressed in ... Adalimumab binds specifically to TNF and neutralizes the biological function of ..... average absolute bioavailability of adalimumab estimated from three studies ...
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Flavonoids protect mice from two types of lethal shock induced by
The protective effect of flavonoids on two types of lethal endotoxic shock was ... TNF-K-induced lethal shock in D-GalN-sensitized mice was also protected by ... Recombinant murine TNF-K was obtained ... concentration in sera was determined by a lipoperoxide .... £avonoids might be dependent on its anti- oxidant action.
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TNF and TNF-receptors: From mediators of cell death - ScienceDirect
Aug 1, 2014 ... Tumor Necrosis Factor (TNF), initially known for its tumor cytotoxicity, is a ... its apparent safety in rodent models of disease, recombinant TNF ... by passive immunization) protected mice against lethal TNF-mediated endotoxemia [24]. ...... to determine if this also occurs with all anti-TNF biologics and in the ...
[ 1-s2.0-S1359610114000781-main.pdf?_tid=c8796036-292c-11e4-bf6e-00000aab0f6b&acdnat=1408623484_e3354c28a510b331ae24d80b2fbe7200 - Read/Download File

then 2800 scientific papers - European Uremic Toxin
as measured by recombinant nucleocapsid proteins. .... Brouckaert P: Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.
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PEGylated recombinant human soluble tumour necrosis factor
REVIEW OF TUMOUR NECROSIS FACTOR ACTIVITY. During the past decade, .... neutrophils in the joint cavity, and its production may be .... eters such as bioavailability, plasma clearance, and terminal ... for soluble TNF.15 To determine the ability of ..... against lethal Escherichia bacteremia in baboons ( Papio anubis) by ...
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Download - Journal of Clinical Investigation
trols shedding of TNF-αand its biological activity in vivo. TACE is a ... TACE- dependent shedding of TNF-α in mouse and human cells. These data .... To determine whether iRHOM2 regulates TACE in human .... Recombinant human C5a and C3a (EMD4Biosciences) and .... myeloid cells prevents lethality from endotoxin.
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Interferon beta 1a, Rebif, Serono - FDA
ABBREVIATIONS: IFN-β, recombinant, human interferon-beta 1a; CHO, Chinese ... LD50, dose which causes lethality in 50% of the animals treated; PBL, ..... pro- inflammatory cytokines tumor necrosis factor-α, lymphotoxin, interferon-γ, and ... several different animal species, to determine the species demonstrating suitable  ...
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Selective inhibition of anthrax edema factor by adefovir, a drug for
lethal factor (LF) (1, 2). As an adenylyl ... profile of cytokines such as tumor necrosis factor α (TNF-α) and interleukin 6 ... kinase, also enters into host cells by its association with PA (9,. 10). ... recombinant proteins were purified from Escherichia coli as described .... 1A) is an orally bioavailable prodrug of adefovir (PMEA), an.
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Jpet Etjournals.org Content Early Jpet.103.059675.full - Journal of
Jan 12, 2004 ... represents a unique class of orally bioavailable small molecule TNF inhibitors that may ... to understand its etiology over more than two decades, the precise .... For MMP assays described here, the source of enzymes was the recombinant human ... The effect of TMI-1 on TNFRII shedding was determined.
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Research Article Dual role of endogenous nitric oxide in tumor
can incite lethal shock, in which cardiovascular collapse is centrally ... revealed a dual role for TNF in certain diseases, promoting ischemic injury on the one ...
[ davis-dual role.pdf - Read/Download File

Phase II trial of curcumin in patients with advanced pancreatic cancer.
Jul 15, 2008 ... Abstract Purpose: Pancreatic cancer is almost always lethal, and the only U.S. Food and Drug ... because of its poor oral bioavailability (16). Therefore, we. Cancer ... did the present phase II study to determine whether oral curcumin has ... and tumor necrosis factor-a–induced binding expression of NF-nB,.
[ Dhillon Clin Cancer Res 14,4491,2008.pdf - Read/Download File

TNF-α: A Paradigm of Paradox and Complexity in Multiple Sclerosis
Nov 23, 2009 ... TNF-α expression and its signalling are regulated at the .... the apoptotic and non -apoptotic pathways, which determines cell survival .... more severe and lethal form of EAE when immunised with ... tion of TNF-α production [126, 127] and bioavailability ... cacy of a soluble recombinant TNF-RI fusion protein.
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Download PDF - Plos
elevation of TNF-a in 1 hr (2 hrs after LPS challenge) with earlier decline to .... Mice were given lethal dose of LPS (100 mg/kg, ip) to induce ... induced by LPS ( Lane 2 in panel D) and its inhibition by OroA (15 mg/kg, ... preparation is bioavailable after iv and ip administrations. ..... Lung wet-to-dry ratio that determines pulmo-.
[ journal.pone.0047403.PDF - Read/Download File

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