Bcl-2 delays macrophage engulfment of human B cells induced to
School, Birmingham, GB. Bcl-2 delays macrophage engulfment of human B cells induced to undergo apoptosis. The capacity to be recognized and engulfed by ...
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Distinct Modes of Macrophage Recognition for Apoptotic and
that macrophages bind and engulf native apoptotic and necrotic cells to similar extents and with similar kinetics .... target cells in which we induced physiological death or triggered pathological ...... undergo physiological cell death, for example , by pathogens .... Bcl-2 delays macrophage engulfment of human B cells induced ...
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PDF (820 KB) - Cell
Oct 28, 2011 ... Thomas S. Griffith1,* and Thomas A. Ferguson2,* ... It is estimated that up to 106 cells die in the human .... T cells induced to undergo apoptosis are immunogenic, not tol- ... kines IL-10 (Gao et al., 1998) and TGF-b (Chen et al., 2001) as ..... tolerance subsequent to engulfment of apoptotic cells (Ferguson.
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Impaired Apoptotic Cell Clearance in the Germinal Center by Mer
Oct 15, 2010 ... Many B cells undergo apoptosis during B cell clonal selection in GCs. ... 2/2. ) mice had significantly higher AFC, GC, and Th1- skewed IgG2 ... macrophages has been described in human patients with systemic ... complement factor C1q facilitate the engulfment of apoptotic cells ...... Bcl-2 stimulation (55).
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Expression of Bcl-2 and Its Homologues in Human - ATS Journals
The Bcl-2 family has been shown to be vital regulators of programmed cell death in numerous ... 7.4% in the absence of IL-5, and induced Bcl-2 mRNA and protein expression, with no detectable change ... IL-3, and granulocyte macrophage colony-stimulating fac- ... hibited apoptosis but not engulfment by phagocytes in.
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Editorial Regulation of granulocyte apoptosis and - Thorax
thermore, the ingestion of apoptotic cells by macrophages, ... pled with the huge potential for these cells to induce tissue ... ery that neutrophils and eosinophils undergo constitutive ... human neutrophils in vitro.27 ... Bcl2 is readily detectable in eosinophils yet is absent from .... 26 Vignaux F, Vivier E, Malissen B, et al.
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FADEEL B et al, 1999. Apoptosis in Human - University of Bath
sis in human disease along with novel apoptosis-based therapeutic modalities ... Abbreviations used: AICD, activation-induced cell death; AIDS, acquired ... caspase recruitment domain; BH, Bcl-2 homology; ced, cell death abnormal; egl ... necrotic cells and a penumbra of cells which undergo delayed apoptotic death (5).
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Download PDF - Plos
Citation: Preta G, Fadeel B (2012) AIF and Scythe (Bat3) Regulate Phosphatidylserine Exposure and ... macrophage engulfment of apoptotic cells [7 ,8]. ... previously reported that overexpression of Bcl-2 prevents PS .... mAb- and staurosporine-induced apoptosis and we noted that the .... undergo phagocytosis [12,35].
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BCL-2 family expression in human neutrophils during delayed and
Human neutrophils spontaneously undergo apoptosis in vivo and in vitro, with a ... reported to be a nuclear factor B (NF-B) inhibitor , also induces ... Bcl-2 protein has been reported to be essential for delayed ... transcriptase (RT)-PCR might detect signals from cells such as ...... but not their engulfment by macrophages.
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Granulocyte apoptosis and inflammatory disease - British Medical
granulocytes whereby the cells undergo apoptosis, a process which controls the functional longevity of .... Apoptoiij. B. Fig. 2 (A) Human. monocytB-derived macrophages that have .... Fas-L appears to induce granulocyte apoptosis in vivo27. Although ... neutrophil apoptosis-inhibitory protems; agents such as Bcl-2 were.
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Regulation of Lymphocyte Survival by the BCL-2 Gene Family
Genes homologous to bcl-2, the oncogene implicated in human follicular lymphoma, play a ... Expression in tumors of bcl-2 and other cell survival genes .... Bcl-2 is now known to inhibit apoptosis induced by a wide range of agents. Enhanced .... ulated to undergo macrophage differentiation, encodes a much larger protein.
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Meeting Report - Cancer Research
Jan 1, 1994 ... the cells undergoing apoptosis, ced-9 controls cell death, but in con- ... involved in engulfment of dying-dead cells but are not involved in cell .... 32~ cells undergo complete arrest in a cell cycle position more ... which bears sequence homology with the human bcl-2 gene. ... delayed onset of apoptosis.
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Regulation of neutrophil FcRIIIb (CD16) - Journal of Leukocyte Biology
following delayed apoptosis in response to GM-CSF and ... Abstract: When neutrophils undergo apoptosis, they lose expression ... Granulocyte-macrophage ... shedding (2) increased mobilization of the internal ... (100,000–200,000 molecules per cell) on the neutrophil cell ..... (B) relative amounts of shed CD16 after this 3-h.
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Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and
Aug 9, 2011 ... Ben A. Crokera,b,1,2, Joanne A. O'Donnella,b,1, Cameron J. Nowellc, Donald Metcalfa ... to undergo cell death, but whether they act cooperatively in ... Fas- induced cell death in neutrophils, but did not examine .... Bcl-2 and Mcl-1 Delay FasL-Induced Neutrophil Apoptosis. ..... engulfment by macrophages.
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Phagocytosis executes delayed neuronal death after focal brain
Oct 7, 2013 ... Jonas J. Nehera,b,1, Julius V. Emmricha, Michael Frickera,2, Palwinder K. Mandera,3, Clotilde ... Delayed neuronal loss and brain atrophy after cerebral ischemia ... age-associated ligands released from dying cells induce a strong ... that the brain's macrophages, microglia, express MerTK (15) as well.
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(CD95) and Fas Ligand on Normal Human Phagocytes
Human neutrophils, monocytes, and eosinophils are known to undergo ... totic morphologic features are generally delayed until 48- ... FasL to induce apoptosis upon interaction with Fas-bearing .... suspended in ice-cold PBS at a concentration of 2 X 10 v cells/ml. ...... role in the regulation of both T cell and B cell develop-.
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Fas Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38
Sep 4, 2000 ... Key words: apoptosis • Bcl-2 • Fas ligand • p38 mitogen-activated protein kinase • ... macrophages (2, 3). ... delayed spontaneous apoptosis of human granulocytes in ... (Fas/APO-1) is required to induce cell death in granulo- ..... wt, (b and e) vav- bcl-2 transgenic, or (c and f) lpr mice were sorted and cul-.
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Mycobacterium tuberculosis–Induced Activation Accelerates
delayed the apoptotic rate of TB-PMN, preserving the CD16. PMN undergo ... susceptible to engulfment by macrophages (12) avoiding the ... In vitro, PMN rapidly undergo ultimately, to the .... cells were resuspended in solution B ( permeabilization) and the mouse anti-human bcl-2 IgG1-FITC–conjugated antibody (An- cell).
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Phagocytosis of Cells Dying through Autophagy Evokes a Pro
Jun 14, 2007 ... human macrophages and non-dying MCF-7 cells. ... calreticulin-mediated recognition, tethering, tickling and engulfment ... distinguish autophagic cell death from apoptosis.2 However, ... cell surface is one of the changes induced when autophagy triggers .... Levine B. Cell biology: autophagy and cancer.
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Autoimmunity and the Clearance of Dead Cells - ScienceDirect.com
Mar 4, 2010 ... In human adults, billions of cells die every day as part of the body's natural processes. ... Mice deficient in the engulfment of apoptotic cells develop systemic lupus ... agent-mediated apoptosis, BH3-only members of the Bcl-2 family are .... It activates microglia and macrophages to undergo chemotaxis by ...
[ 1-s2.0-S0092867410001297-main.pdf?_tid=8c0dfc94-2fc4-11e4-9735-00000aab0f01&acdnat=1409348373_165f0e57a1fe0b6a03addb90e4d3d94c - Read/Download File