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Age-related Alterations of Gene Expression Patterns - UCI Webfiles
cellular and genomic integrity, and alterations of growth, differentiation ... demonstrated that gene expression changes associated with aging in CD8+ T cells.
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Age-associated alteration of gene expression patterns in mouse
Aug 18, 2004 ... The alteration of gene expression patterns in aging cells and organs has been .... genes encoded in the nuclear genome but related to 'energy.
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Epigenetics of Aging and Aging-related Disease - The Journals of
Aging is associated with a wide range of human disorders, including cancer, diabetes, cardiovascular, and ... broad genome architecture and the epigenomic landscape. ... resulting in alterations of the gene expression, epigenetic landscape ...
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Human aging is characterized by focused changes in gene
May 31, 2011 ... expression may therefore provide potential biomarkers of aging. Similarly ... wide alterations in gene expression associated with chronological age in ..... on residual expression variability failed to reach genome-wide signifi-.
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Genome Instability and Aging - Annual Reviews
There are three types of genome alterations: (a) chemical damage to the DNA of the ... control gene expression but do not affect the actual base pair sequence of DNA. Genome instability has been implicated as a cause of aging since the ...
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Aging-associated changes in cardiac gene expression - CiteSeerX
Keywords: Aging; Gene expression; Gene array analysis; Heart failure; Statistics. 1. Introduction ... how this approach can be used to identify genetic causes of aging in .... of aging- associated alterations in gene expression had actually been .
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Transcriptional profiles associated with aging and middle age-onset
Nov 12, 2002 ... Interest- ingly, CR also resulted in alterations in gene expression consistent ... mitochondrial genomic rearrangements associated with aging (22). To infer ... of aging on gene expression, the transcriptional activities of hearts.
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Gene expression changes in the course of normal brain aging are
Oct 7, 2008 ... Alterations at the gene expression level may help account for ... Understanding the aging-related changes in gene ... genes in the genome.
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Transcriptional Profiles Associated with Aging and Middle - JStor
ingly, CR also resulted in alterations in gene expression consistent we with preserved ... mitochondrial genomic rearrangements associated with aging (22). Thi.
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Aging shapes the population-mean and -dispersion of gene
Feb 17, 2016 ... Keywords: aging, gene expression, human brain, age-related gene, ... aging. The Genotype-Tissue Expression (GTEx) project was established to determine how genetic ..... characterizing the age-related expression alteration.
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Aging and Gene Expression in the Primate Brain - eScholarship
Feb 18, 2005 ... changes associated with aging to be studied in both model organisms and various human tissues. ... patterns of age-related gene expression alterations. In humans ... oxygen species (ROS), thus providing genetic evidence in.
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Using whole-genome transcriptional analyses to identify molecular
ena, such as aging, where multiple genetic and biochemical pathways are expected ..... prevents age-related alterations in gene expression in the heart. Physiol.
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Meta-analysis of age-related gene expression profiles identifies
Jan 11, 2009 ... alterations in the expression of genes related to apoptosis, cell cycle and cellular ... Considering the number of aging gene expression studies.
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Aging shapes the population-mean and -dispersion of gene
May 19, 2016 ... Human aging is associated with cognitive decline and an increased risk of neurodegenerative ... demonstrate that age-related gene expression is brain region-specific, ... genome-wide patterns of change in gene expression associated with aging. ..... characterizing the age-related expression alteration.
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Epigenetics and aging
6 days ago ... that occur without any alteration of the underlying DNA sequence. Al- though the ... formative organismal model for aging studies with its genetic tools, ..... due to the resulting increase in histone gene expression that counters.
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TRANSCRIPTIONAL PROFILE OF AGING IN C - CMGM Stanford
Gene expression changes during C. elegans aging. 2 ... rate of aging, increased resistance to stress, decreased metabolic rate, or alterations in a program ... For example, genetic experiments in Caenorhabditis elegans have shown that .... time course, and found that the variance in gene expression due to age was greater ...
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Temporal and spatial transcriptional profiles of aging in Drosophila
Jul 10, 2007 ... Temporal and tissue-specific alterations in gene expression have profound ... spatial changes associated with aging from multiple tissues at multiple ages, ... basis and a valuable resource for further genetic and genomic ...
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Genome-wide Views of Aging Gene Networks
A gene expression signature for aging is a quantitative phenotype that gives a high-resolution ... Using high-density gene arrays to measure age-related changes in ..... scriptional alterations consistent with a state of reduced oxidative stress.
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Whole transcriptome sequencing of the aging rat brain reveals
Integrative Genomics of Ageing Group, Institute of Integrative ... Therefore, in addition to changes in the expression of protein-coding genes, changes in transcript ... Sophisticated high-throughput approaches enable age-related molecular ...... splicing changes and alterations in the levels of various types of RNA genes to be ...
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SIRT1 Redistribution on Chromatin Promotes Genomic Stability but
Nov 26, 2008 ... Genomic instability and alterations in gene expression are hallmarks of eukaryotic ... of genes that cause sterility, a characteristic of yeast aging.
[ 1-s2.0-S0092867408013172-main.pdf?_tid=c20c0146-4d20-11e4-a18d-00000aab0f27&acdnat=1412576561_23d6cd821de656bba46db628f501ac04 - Read/Download File

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