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COMBINATORIAL
on combinatorial techniques. Frankly, the ... new field called combinatorial chemistry— design a synthesis .... ies (using a one bead, one compound ap- proach) .... around a tyrphostin template, or core struc- ture. Next ... as directed sorting (9).
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Small Molecules for Dissecting Endomembrane Trafficking: A Cross
Apr 18, 2013 ... Tyrphostin A23, endocytosis, interfering between tyrosine motifs and ... sorted for trafficking through the Golgi apparatus and the trans-Golgi ... The TGN compartment also produces clathrin-coated vesicles directed to the ..... to small molecules from large combinatorial (synthetic) libraries. ... Methods Mol.
[ 1-s2.0-S1074552113001129-main.pdf?_tid=35faae22-5dcf-11e4-982c-00000aacb360&acdnat=1414410707_166e977f8ab5243634b376868e5ffb1e - Read/Download File

Automated High-Content Live Animal Drug Screening Using C
Nov 16, 2010 ... synthetic combinatorial chemistry compound collections and the development of high- ... chemical genetic (i.e., phenotype-directed) screens using live animals that ... elegans sorted into a 384-well plate (Figure 1A). ... regression, was due to the inability of algorithm to resolve ...... tyrphostin AG 879c. 1236.5.
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Download as a PDF - CiteSeerX
Such techniques have been applied to, for example, antibody–antigen, receptor– ligand, signal .... faces (ethylenediamine immobilised via NHS/EDC chemistry,.
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Download PDF - Plos
May 15, 2012 ... methods for embryo dispensation, compound delivery, incubation, imaging and ... directed strategies has been accelerated thanks to advances in genomic research, combinatorial chemistry and laboratory auto- ... for in vivo high-content and high-throughput screenings using ... sorting criteria and width.
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Get PDF (254K) - Wiley Online Library
array assembly methods 93 array-forming ... activation via stannoxanes 224. - selective ... combinatorial chemistry 9.28.39 controlled pore ... fluorescence activated cell sorting (FACS) 44 fluorophores ... light-directed 53 ... tyrphostins 52, 89. U.
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UNTANGLING THE ErbB SIGNALLING NETWORK - Unisciel
tive, multilayered network, in which combinatorial expression and ... the mantra that molecular understanding yields clinical benefit: over 25,000 women with.
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Spatio-Temporal Cellular Dynamics of the - The Plant Cell
Oct 19, 2012 ... is directed through different endosomal compartments, and in- .... tive, high- throughput, live-cell imaging techniques and developed ... targeted endosomal sorting that is dependent on the activation ... Inhibition of protein synthesis by .... Tyrphostin A23 (TyrA23) is a well-described inhibitor of clathrin-.
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Blue-light-activated phototropin2 trafficking from the cytoplasm to
May 12, 2014 ... and the light chain2 of clathrin via bimolecular fluorescence complementation. .... is directed to different endosomal compartments, involving.
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Integrin-dependent Translocation of Phosphoinositide 3-Kinase to
clude physical association with specific proteins via the src homology 2 (SH2) ... in intracellular sorting and down-regulating processes in- ... PtdIns(3,4)P2 synthesis in platelet is due to the action of a ..... and activated for 5 min by thrombin as indicated in Materials and Methods. ... Translocation of Ptdlns 3- Kinase Is Directed.
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epidermal growth factor receptor kinase inhibitor tyrphostin-AG1478, and re- expression was prohibited by the protein synthesis inhibitor cylcoheximide; the lysosome inhibitor ... fluid secretion via modulation of epithelial cell Ca2+ and .... Methods. Tissue samples and human colonic crypt isolation. This study was performed ...
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The epidermal growth factor receptor family as a central element for
to be characterised by molecular genetic methods (Ullrich et al. ... elements and/ or autocrine stimulation through aberrant growth factor loops is frequently linked  ...
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Get cached PDF (1 MB) - Core
Aug 31, 2009 ... rational combinatorial therapies to sensitize tumor cells toward EGFR-targeted ..... inhibitor tyrphostin AG1478 as well as the ETA-specific ... via xenografts, animal models utilizing other methods of ... Cell Sorting ... Immunocyto-chemistry/ .... however, as it is directed against deletion mutants of EGFR.
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Targeting the Epidermal Growth Factor Receptor in Epithelial
Aug 31, 2009 ... rational combinatorial therapies to sensitize tumor cells toward EGFR-targeted ..... inhibitor tyrphostin AG1478 as well as the ETA-specific ... via xenografts, animal models utilizing other methods of ... Cell Sorting ... Immunocyto-chemistry/ .... however, as it is directed against deletion mutants of EGFR.
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Uveal melanoma and macular degeneration - KI Open Archive
This thesis highlights the possibility of using IGF-1R as a prognostic marker for uveal .... sharing his big skills on molecular biology techniques. Magnus Axelson  ...
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