A cellular model for sporadic ALS using patient-derived induced
A cellular model for sporadic ALS using patient-derived induced pluripotent ... of sporadic ALS patients' fibroblasts into induced pluripotent stem cells (iPSC) and ...
[ 1-s2.0-S1044743113000730-main.pdf?_tid=815c38cc-43a8-11e4-b036-00000aacb35e&acdnat=1411535353_a7eda115f1825d48797d7cb0dd8dc2bf - Read/Download File
Patient-Specific Induced Pluripotent Stem Cells - ACS Publications
Aug 31, 2015 ... Human induced pluripotent stem cells, particularly derived from patients, are an ... that use patient-derived iPSCs to model disease and pharmacologically ... cellular phenotypes seen in the iPSCs to the actual diseases, and we will highlight .... fibroblasts from three sporadic-ALS patients with unknown.
[ acs.jmedchem.5b00789 - Read/Download File
The potential of induced pluripotent stem cells in models of
pluripotent stem cell-based modelling of neurological disorders, canvassing ... be especially useful for studying sporadic or idiopathic forms of a disease to ... by Bilican et al (2012) of iPSCs derived from patients with ALS report an increased.
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Human-induced pluripotent stem cells - Human Molecular Genetics
Jun 13, 2014 ... of human induced pluripotent stem cell (iPSC) models has greatly enhanced our ability .... iPSCs derived from HD, PD and ALS patients have been successfully ..... models of AD using sporadic AD patients as well as familial.
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Induced pluripotent stem cells (iPSC) and neurologic disease
Aug 9, 2011 ... models available to study neurological diseases are limited and .... recently reported in sporadic ALS patients with no identified genetic mutations (15). ... iPSC-derived cells can also recapitulate the non-cell autonomous ...
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Intraspinal Stem Cell Transplantation for Amyotrophic - Neuralstem
ALS, because they come armed with equally complex cellular machinery and may modulate the local microenviron- ... muscle.41 This was then applied to rodent models of. ALS ...... sporadic ALS using patient-derived induced pluripotent stem.
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Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to
Oct 28, 2015 ... A cellular model for sporadic. ALS using patient-derived induced pluripotent stem cells. Mol. Cell. Neurosci. 56(C):355–64. 63. Neumann M ...
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Modeling human neurological disorders with induced pluripotent
Keywords: human disease model, induced pluripotent stem cells, neurological ... the use of iPS cells derived from patients with certain neurological diseases ...
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The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and
Jan 13, 2016 ... cell lines and how it would increase knowledge about the ALS/FTD disease ..... for sporadic ALS using patient-derived induced pluripotent.
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Multiple Sclerosis Patient-Specific Primary Neurons - Plos
May 9, 2016 ... cell- and patient-specific paradigm to provide an in vitro model within which to perform future ... sclerosis patients' urine and transfected with pluripotency- inducing episomal factors. Sub- sequent induced ...... A cellular model for sporadic. ALS using patient-derived induced pluripotent stem cells. Mol Cell ...
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Early detection of structural abnormalities and cytoplasmic
Consequently, our ALS skin model could represent a renewable source of ...... A cellular model for sporadic ALS using patient-derived induced pluripotent stem ...
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Directly converted patient-specific induced neurons mirror the
Jan 18, 2016 ... ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS protein. ALS patients' fibroblasts or induced pluripotent stem cell ... Q519E): two de novo mutations in sporadic ALS and one in familial ALS ... nuclear clearance was detected in all patient-derived iNeurons, and ...
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ALS mutant FUS proteins are recruited into stress granules in
Apr 23, 2015 ... Patient-derived induced Pluripotent Stem Cells (iPSCs) provide an opportunity to ... spinal cord neural cells provides an in vitro model mimicking the physiological conditions. ... of ALS cases is familial (fALS), while the rest is sporadic (sALS). .... We generated iPSC lines from two ALS patients with FUS.
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human motor neurons derived from induced pluripotent stem (ips) cells
HUMAN MOTOR NEURONS DERIVED FROM INDUCED PLURIPOTENT STEM ... obtained from genetic and sporadic ALS patients and age-matched healthy ... expect that the generation of iPS cells will allow to model sporadic forms of ALS and to ... The team has set up the iPS cell technology using skin fibroblasts from ...
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Small Molecule Screening in Human Induced Pluripotent Stem Cell
Feb 21, 2014 ... types associated with patient-specific human stem cell-derived ...... (2013) A cellular model for sporadic ALS using patient-derived induced.
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Mutant induced pluripotent stem cell lines recapitulate aspects of
Apr 10, 2012 ... fibroblasts by using induced pluripotent stem cells (iPSCs). Here ... of both sporadic and inherited FTLD-TDP (a subgroup of ... Most cellular and animal models of ALS and FTLD-TDP ... effects of endogenous mutant TDP-43 in iPSC- derived human neurons from an ALS patient carrying the M337V mutation.
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Astrocyte pathology and the absence of non-cell autonomy in an
Mar 19, 2013 ... imal models and is a dominant feature of all human ALS pathology. (4, 6, 10). Collectively ... determination with human induced pluripotent stem cell (iPSC) lines derived from patients carrying ALS disease-causing mutations may provide ..... cell-autonomous toxicity of human sporadic or, indeed, SOD1MT.
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Induced pluripotent stem cells: methods, disease modeling, and
Dec 21, 2015 ... Key words: Induced pluripotent stem cells, reprogramming methods, ...... cellular model for sporadic ALS using patient-derived induced.
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PDF File - Neuroregeneration Laboratories
modeling using patient-derived induced pluripotent stem cells (iPSCs) contribute to better ...... A cellular model for sporadic ALS using patient- · derived induced ...
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A Comprehensive Library of Familial Human Amyotrophic - Plos
Mar 11, 2015 ... ALS disease mechanisms is largely derived from rodent model studies, ... comprehensive library of a total 22 of fALS patient-specific induced pluripotent stem cell ... mon sporadic form(s) of ALS; (3) lack of proper pharmacokinetics, (4) lack of ... In addition, very recent studies with ALS C9orf72 iPS cell lines ...
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